User:Rosewater3/sandbox

In July 2017, researchers led by Jennifer Doudna from the University of California at Berkeley, in Berkeley, California, using electron microscopy and X-ray crystallography, at the Advanced Light Source at Lawrence Berkeley National Laboratory, the Stanford Linear Accelerator Center, and the HHMI electron microscope facility at UC Berkeley, discovered how Cas1-Cas2, the proteins responsible for the ability of the CRISPR immune system (CRISPR means: clustered regularly interspaced short palindromic repeats) in bacteria to adapt to new viral infections, identify the site in the genome where they insert viral DNA so they can recognize it later and mount an attack. A protein called IHF plays a crucial role in this process. Scientists also discovered that Cas-1 inhibits Cas-2/3 enzymatic activity as a nuclease and in the same discussion postulated that Cas1-Cas2 originated evolutionary as a toxin-antitoxin complex. This could result in a change in the evolutionary model of the Cas1-Cas2 complex.