User:Rsriram0812/sandbox

Cognitive Effects
In most elderly people, presence of severe WMH and medial temporal lobe atrophy MTA was linked with an increase in frequence of mild cognitive deficits. Studies suggest that a combination of MTA and severe WMH showed more than a fourfold increase in the frequency of mild cognitive deficits. It's also been consistently shown that severe WMH is known to be associated with gait disorders, impaired balance and cognitive disturbances. Certain features of gait pattern associated with WMH are: slight widening of the base, slowing and shortening of stride length and turning en bloc. Speed of cognitive processes and frontal skills may also be impaired in people with WMH. It is also thought that WMH patients have a negative impact on cognition in Alzheimer's disease population. Pathological signs of oligodendritic apoptosis and damage to axonal projections have been evident. Sufficient damage to the axons that course through WMH can cause adequate interference with normal neuronal functions.

=References=