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Early life and education
José Gregorio Hernández Cisneros was born on October 26, 1864 in Isnotú, a small village in the state of Trujillo in the United States of Venezuela (now Bolivarian Republic of Venezuela.) He was the first of seven children of Benigno María Hernández Manzaneda and his wife Josefa Antonia Cisneros Mansilla.

He spent the entirety of his childhood in his hometown, where his mother worked as a housekeeper and his father sold pharmaceuticals and livestock. Hernández was baptised on January 30, 1865 in the Colonial Temple of Escuque (now the Parochial Church of Niño Jesús de Escuque.) He received the sacrament of Confirmation on December 6, 1867 by Juan Bonet, Bishop of Mérida.

At the age of thirteen, Hernández expressed to his parents his desire to go to law school and become a lawyer, but was convinced by his mother to pursue a career in medicine. So, in 1878, he began his long and rigorous journey from the Andes Mountain Range in Trujillo to Caracas. He enrolled in Colegio Villegas, one of the country's most prestigious schools at the time, where, in 1882, he graduated with a baccalaureate in philosophy.

After completing his high school education, Hernández enrolled in Universidad Central de Venezuela (UCV) to begin his medical studies. Throughout his six years of at UCV, he was described by his professors as a student of outstanding academic performance and conduct.