User:RuchenCAI/sandbox

Week 2 Articles of Interest
1. Astressin-B: It is a corticotropin releasing hormone antagonist that blocks ATCH and cortisol synthesis. Two relative researches on its functions are provided. However, the two sources are both primary source, which may be biased.

2. CD96: It is a receptor on T cells and NK cells. The part in the article that talks about its function is not properly cited ([citation needed] notion). Also, the author was not certain about its exact functionality.

3. Deoxyuridine monophosphate: It is a metabolic intermediate. Some of its identifiers (ChEMBL and ChemSpider) are not verified. One of the source is from a review paper, but the paper was published in 1979, which could be outdated.

4. Chondroitinase treatment

5. Quinoxalinedione

-There is room for expansion in all these articles. Deoxyuridine monophosphate and Quinoxalinedione may not have enough overall content to add. - Dr. Tienson-Tseng

(updated)
4. Chondroitinase treatment: It is a treatment to restore eye vision and potentially spinal injury. However, the source about its utility in spinal injury treatment is from BBC news in 2008, about a new medical research finding. More reliable source on this research could be updated.

5. Cytochalasin E: It is an inhibitor of actin polymerization and tumor growth. Its hazard is outdated and some of its identifiers are not verified. One of its source is from a data base about which I am not sure if it is reliable.

Week 3 Reference for CD96
"Coming of Age: CD96 Emerges as Modulator of Immune Responses." A review article on CD96's structure, function, clinical potential, and future research areas.

"TIGIT and CD96: new checkpoint receptor targets for cancer immunotherapy." A review article on the research of CD96 and TIGIT for cancer checkpoint receptors.

"The receptors CD96 and CD226 oppose each other in the regulation of natural killer cell functions." Compares CD96's function with other cluster of differentiation.

"Structural Basis for CD96 Immune Receptor Recognition of Nectin-like Protein-5, CD155." Provides structural basis for CD96's function.

"The murine pan T cell marker CD96 is an adhesion receptor for CD155 and nectin-1." Frequently cited by review articles and databases.

Week 6 first draft
= CD96 (draft) =

Function
I plan to write about its function of adhesion and how it effects T cell and NK cell activation.

Structure
I will introduce its extracellular Ig-like domain and cytoplasmic domain

Clinical Applications
Increasing clinical research and reviews came out after the last edit of this article has demonstrated CD96’s importance in cancer immune checkpoint target. I plan to add CD96’s role in T-cell and NK-cell inhibition.

Interactions
I plan to mainly write about CD96’s interaction with CD155, which is crucial to its function, and CD266 (and TIGIT), which is closely related to its application in cancer immunology.