User:Ruwan23/sandbox

Outline
 * 1) History
 * 2) MWC model
 * 3) emergence of KNF model by Koshland et al.
 * 4) Rules guiding the KNF model
 * 5) induced-fit model: change in conformation of enzyme to improve binding affinity to transition state, catalyzing reaction
 * 6) KNF model is conducive to this, where each ligand binding site changes affinity to the ligand, or the transition state of the ligand in the case of catalysis
 * 7) Comparison to the MWC model
 * 8) KNF predicts negative and mixed cooperativity, not possible with the MWC model
 * 9) T and R state vs. induced fit
 * 10) Adherence to Biochemical Data
 * 11) Hemoglobin by the MWC model
 * 12) hemoglobin by the KNF model