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Chemical composition
Dihydro-flavonol glycosides(astilbin, neoastilbin, isoastilbin, neoisoastilbin, (2R, 3R)-taxifolin-3'-O-beta-D-pyranoglucoside) have been identified in the rhizome of Smilax glabra as well as smitilbin, a flavanonol rhamnoside. Smiglabrone A and Smiglabrone B are phenylpropanoid-substituted epicatechins that have also been isolated from the root.

Sarsasapogenin, a steroidalsapogenin, can also be found in S.glabra.

Use of S.glabra in Traditional Chinese Medicine
The root of the S.glabra is used in Traditional Chinese Medicine (TCM) to treat dysentary, joint pain and colds. S.glabra is grown in Southern China. The rhizome of the plant is collected and dried during all seasons for herbal use. The dried root is mixed with water for oral use. S.glabra is used in TCM to restore balance in the body in response to yin disease by removing Dampness and toxicity.