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Effects on Obesity
It has been proposed that BPS has the potential to affect body weight, and several studies have found a correlation between exposure to bisphenols and increased body weight. This is thought to be due to an accumulation of lipids in adipocytes i.e. a build-up of fat in fat cells. It has also been suggested that BPS leads to the formation of new adipocytes as exposure to it increases the expression of related markers. A correlation between exposure to BPS before birth and being overweight has been found in mice, although this was only found when they were also fed a high fat diet.

The pathway through which BPS acts on cells to increase body weight is suggested to be different to the pathway through which BPA acts, even though they have very similar chemical structures.

Only one study has demonstrated a decrease in body weight after BPS exposure, and the affected mice quickly regained the weight they had lost.

Other Metabolic Effects
BPS levels in the human body can be measured in the urine. In one study of children, there was a significant correlation between urinary levels of BPS and insulin resistance, abnormal kidney function and abnormal vascular function.

It has been suggested that there is a link between gestational diabetes mellitus and urinary BPS. Therefore, exposure to BPS may be a risk factor for developing the condition.