User:SJyothiK/sandbox

Article Evaluation
Cre-Lox recombination article

- article is rated C with mid importance

- there is a warning banner urging the need for additional citations to reliable sources for verification

- the article has a warning banner urging the need for additional citations to reliable sources for verification

- some value statements exist that should be reworded : - very short section on implementation of multiple loxP site pairs --> meaning unequal emphasis of subtopics --> could have emphasized experimental usage and breakthroughs discovered using cre-lox recombinase
 * the clear demonstration of its usefulness
 * provides the best experimental control that presently exists in transgenic animal modelling to link genotypes to phenotypes

- a respectable amount of citations do exist, all mainly primary articles of research - maybe use of more textbook links or perspectives articles could be used

- need to clearly explain how the deletions and inversions are functioning seperately not briefly discussing that it just happens in the same sentence

Article Topic Choices
- stem cell genomics : Talk:Stem cell genomics

- CED9 - CED9 (gene)

- stem cell chip : Stem cell chip

- metabolic imprinting : Metabolic imprinting

- epigenetic code : Talk:Epigenetic code

- segmentation gene: Segmentation gene

Gene Signature Detection Timeline
In the mid 1990's there were 2 studies conducted that identified unique approaches to analyzing global gene expression of a genome which collectively promoted the value of identifying and analyzing gene signatures for physiological relevance. The first study reports a technique known as Serial Analysis of Gene Expression (SAGE) that hinged on sequencing and quantifying mRNA samples which acquired levels of gene expression that eventually revealed characteristic gene expression patterns.

The second study identified a technique that is now widely known as the microarray which quantifies complementary DNA (cDNA) hybridization on a glass slide to analyze the expression of many genes in parallel. Fast forward to today, this technique has revolutionized research in genetics and DNA chip technology as it is a widely adopted technique to profile gene expression signatures such that these physiological responses can be cataloged. This catalogue of prognostic, diagnostic and predictive gene expression signatures allow for predictions of onset of pathogenic diseases in patients, tumour and cancer classification , and enhanced therapeutic strategies that predict the optimal target candidates subjects and candidate genes.