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= Gestational choriocarcinoma = From Wikipedia, the free encyclopedia

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(diff) ← Previous revision | Latest revision (diff) | Newer revision → (diff) Jump to navigationJump to search Gestational choriocarcinoma is a malignant trophoblastic tumour arising from any gestational event during pregnancy in the reproductive female. Women with gestational choriocarcinoma may present with abnormal vaginal bleeding, persistent markedly elevated βhCG, or a history of prior pregnancy. Most patients develop gestational choriocarcinoma shortly after gestational anomalies, but pathology may occur after a long latency of years. It may occur during pregnancy. Often, gestational choriocarcinoma happens after a growth of some sort in the womb (pregnancy, tumor, mole, cyst)

Contents

 * 1Diagnosis
 * 2Treatment
 * 3Prognosis
 * 4References

Diagnosis
Grossly, a red hemorrhagic mass is seen in the uterus, though it may vary in size. Often, diagnosis is presumptive, and based on clinical findings and the identification of a malignant trophoblast. One prevalent symptom is vaginal bleeding after a pregnancy, abortion, or hydatid mole. A pregnancy test will be positive even if there is no embryo/fetus.

Due to the wide variety and atypical clinical presentations of the disease, a confirmed diagnosis usually happens after the disease has progressed to a late clinical stage.

Treatment
Chemotherapy is the treatment of choice. Hysterectomy and radiation could be necessary.

Prognosis
At the time of diagnosis, more than 90% of patients already have lung metastases, though there are also less frequent metastases to the brain and liver. With chemotherapy, there is an 80% 5-year survival rate. Ultimately, death is related to liver and brain metastases.