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To summarize Wikipedia's Five Pillars as practice in editing and formatting in Wikipedia. The summary is based on the information obtained from the Wikipedia website .

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Overview of Carrier Screening Methods for Tay-Sachs Disease
Tay-Sach disease (TSD) is an autosomal recessive disorder that affects different ethnicities such as Ashkenazi Jewish, French Canadians, Irish and Cajuns. Hexosoaminidase A, encoded by the HEXA gene, is one of two forms of the hexosoaminidase enzyme, and it is comprised of an α and a β subunit. A defect in the α subunit results in TSD .TSD carrier screening is currently been performed using an enzyme-based test that measures hexosoaminidase A activity, and DNA-based tests that screen for specific HEXA mutations. A new method, next-generation DNA sequencing (NGS) is now available for carrier screening ). Each of these methods has its advantages and disadvantages; however a combination of these methods can be used to screen TSD carriers of diverse ethnic populations.

Combined references for Capping Enzyme Article

 * 1) ^ Cho, Eun-Jung; Toshimitsu Takagi, Christine R. Moore, Stephen Buratowski (1997). "mRNA capping enzyme is recruited to the transcription complex by phosphorylation of the RNA polymerase II carboxy-terminal domain". Genes and Development (11). doi:10.1101/gad.11.24.3319. Retrieved 25 February 2014.
 * 2) ^ Shibagaki, Yoshio; Naoto Itoh, Hisafumi Yamad, Shigekazu Nagata, Kiyohisa MizumotoS (August 30, 1991). "mRNA Capping Enzyme". The Journal of Biological Chemistry. 14 267 (May): 9521–9528. Retrieved 25 February 2014
 * 3) ^ Neugebauer, KM (2002 Oct 15). "On the importance of being co-transcriptional.". Journal of cell science 115 (Pt 20): 3865–71..
 * 4) ^ Bentley, DL (2005 Jun). "Rules of engagement: co-transcriptional recruitment of pre-mRNA processing factors.". Current opinion in cell biology 17 (3): 251–6..
 * 5) ^ Cramer, P; Srebrow, A; Kadener, S; Werbajh, S; de la Mata, M; Melen, G; Nogués, G; Kornblihtt, AR (2001 Jun 8). "Coordination between transcription and pre-mRNA processing.". FEBS letters 498 (2-3): 179–82..
 * 6) http://genesdev.cshlp.org/content/12/22/3482 - Structure: in yeast the capping enzyme is composed of two subunits, the mRNA 5′-triphosphatase (Cet1) and the mRNA guanylyltransferase (Ceg1; Regulation: yeast mRNA guanylyltransferase is regulated by allosteric interactions with both the triphosphatase and CTD;
 * 7) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC316976/ - Function: indicates when mRNA capping occurs (after transcription initiation and before other processing events such as adenylation); its substrate; phosphorylation of CTD acts as signal for binding of capping enzyme
 * 8) http://mcb.asm.org/content/24/14/6184.full - Function: mRNA capping enzyme activity is coupled to an early transcription elongation;
 * 9) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC312735/#B24 – Activation of enzyme: ecognition and activation of the mammalian guanylyltransferase by as few as two phosphorylated heptads
 * 10) http://www.ncbi.nlm.nih.gov/pubmed/10198643 - Activation of enzyme: information on how mRNA capping occurs, and what is involved; CTD peptides containing Ser-5-PO4 stimulate guanylyltransferase activity by enhancing enzyme affinity for GTP;
 * 11) http://www.ncbi.nlm.nih.gov/pubmed/9770468 - Active site of the mammalian capping enzyme that is responsible for binding to mRNA and the mechanism involved, also describes other molecules involved.
 * 12) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549306/ - Function: explains the process of capping, and the three enzymes involved in this process, importance of capping, and how magnesium plays a factor
 * 13) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142331/ - Function: describes the interaction between capping enzyme and phosphorylated CTD
 * 14) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3783409/ - Impact/role: the importance of he N7-methyl guanosine cap in mRNAs stability, maturation, transportation and translation
 * 15) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002257/ - Regulation: image of capping process; regulation of capping by Myc proteins.
 * 16) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC419647/ - Impact of enzyme: the role of CE in promoter clearance and its functional interactions with different factors that are involved in promoter clearance
 * 17) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3121809/ Function: structure of guanyltransferase domain of human mrNA Capping enyzm; provides a good description of the capping process
 * 18) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2770090/ Regulation: Spt5 allosterically activates the cap guanylyltransferase

Images on mRNA structure

 * 1) http://www.rcsb.org/pdb/results/results.do?qrid=EFD792F6&tabtoshow=Current - Structure: Images of the enzymes at different stages of the capping process
 * 2)  File:PDB 1ckm EBI.jpg
 * 3)  File:PDB 1i9s EBI.jpg
 * 4) http://www.ncbi.nlm.nih.gov/Structure/mmdb/mmdbsrv.cgi?uid=91979 - Structure: 3D structure of Mammalian capping enzyme
 * 5) http://www.ncbi.nlm.nih.gov/pubmed/11350947 - Structure: RNA Triphosphatase domain of mammalian capping enzyme
 * 6) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743798/figure/F1/ - has a figure illustrating the capping of mRNA in both nucleus and cytoplasm
 * 7) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465734/ good figure on the capping on Ser5

Lead Section
Build upon the current description to provide an overview of the capping enzyme. In this section provide a description of the enzyme, common names, where the process occurs in the cell, structure, it’s function, its affect on other cell activities and factors that affects its function.

Structure
A description of the enzyme, and provide an image to provide a visual aid (#4 in images section-3D structure).

Function
Describe the enzyme’s function, factors that it requires to perform this activity, location of the activity and its specificity. If possible, provide an image of the whole process for a visual aid (#1 in images section-different stages of the capping process). Identify the active site of the protein that is responsible for binding to mRNA and the mechanism that occurs there.

Impact of the enzyme’s activity
For example, the purpose of capping mRA

Regulation of the enzyme
Factors that affect the activity of the enzyme; insert images that illustrate the regulation of the enzyme

See also Section
Link to other topics such transcription, RNA Polymerases, RNA Polymerase II