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Definition
Cyclic Tetrapeptides (CTPS) are a sequence of 4 amino acids usually cyclized through a amide bond between the N-terminus amide and C-terminus carboxyl, also known as "head to tail" cyclization.

Naturally occuring cyclic tetrapeptides
A range of naturally occurring CTPs have been discovered which have plethora of biological activity. Table 1 describes some briefly.

Propsed uses as protein reverse turn mimics
Work by Arbor, Che, and Marshall has computationally probed CTPs as possible turn mimetics.

Future work
While several CTPs have been structurally described through NMR or X-ray crystallography a much larger set has been predicted computationally. Taking a predicted CTP conformation and modifying it to mimics a well known reverse turn and testing for structural similarity and binding affinity would be a significant next step in the use of CTPs as therapeutics.