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Dr. Sain Singh

Sain Singh (born in 1994) is a chemist in India. His research work is mainly focused on the design and development of new organic and inorganic molecules. Then the developed molecules they utilized as catalysts for various organic transformation reactions and as drug molecules for various biological applications, including DNA interaction, inhibition of protein aggregation like prion protein aggregation, Amyloid beta peptide aggregation study, anticancer, antibacterial, antitubercular, wound healing, etc.,

Education

Singh received his B. Sc. in Chemistry, Botany, and Zoology from Sri Guru Ram Rai P.G. College Dehradun (affiliated to Hemwati Nandan Bahuguna Garhwal (A Central University) University Srinagar, Uttarakhand, India) in 2015. He then moved to Dayanand Anglo Vedic P.G. college for his M. Sc. in 2015 and completed in 2017. After that, he moved to Indian Institute of Technology Roorkee, India for doctorate degree and completed in 2023. Next, Dr. Singh moved to Guangdong Technion Israel Institute of Technology for his research work, where he worked on the organometallic chemistry, catalysis, and mechanistic investigations.

Research articles

[1]    Singh, S.; Choudhury, A. R.; Ghosh, K. “Facile synthesis of quinolines and N-alkylation reactions catalyzed by ruthenium pincer type complexes: Reaction mechanism and evidences for ruthenium hydride intermediate”. ''Mol. Catalysis 549'', 113424, 2023. ( https://doi.org/10.1016/j.mcat.2023.113424 ). (IF: 4.6)

[2]   Singh, S.; Navale, G. R.; Mahale, M.; Chaudhary, V. K.; Kodam, K.; Ghosh, K. "Photodissociation of nitric oxide from designed ruthenium nitrosyl complex: Studies on wound healing and antibacterial activity" Nitric Oxide 129, 30-40, 2023. ( https://doi.org/10.1016/j.niox.2022.09.003 ). (IF: 4.898)

[3]    Singh, S.; Chaudhary, P. K.; Prasad, R.; Singh, U. P.; Ghosh, K. “Visible light induced generation of nitric oxide from designed ruthenium nitrosyl complex and studies on antibacterial activity” J. Molecular Structure 1310, 138323, 2024. ( https://doi.org/10.1016/j.molstruc.2024.138323 ). (IF: 3.8)

[4]   Singh, S.; Navale, G. R.; Agrawal, S.; Singh, H. K.; Singla, L.; Sarkar, D.; Sarma, M.; Choudhury, A. R.; Ghosh, K. “Design and synthesis of ruthenium complexes and their studies on the inhibition of amyloid β(1-42) peptide aggregation” ''Int. J. Biol. Macromol., 239'', 124197, 2023. ( https://doi.org/10.1016/j.ijbiomac.2023.124197 ). (IF: 8.025)

[5]   Singh, S.;† Navale, G.;† Agrawal, S.; Ghosh, C.; Choudhury, A. R.; Roy, P.; Sarkar, D.;  Ghosh, K. “DNA binding, antitubercular, antibacterial and anticancer studies of newly designed piano-stool ruthenium(II) complexes” Dalton Trans.,  51, 16371-16382, 2022. ( https://doi.org/10.1039/D2DT02577A ). (IF: 4.569)

[6]   Singh, S.;† Kumari, S.;† Ghosh, K. “Copper(II) Nitrate Catalyzed Azide–Alkyne Cycloaddition Reaction: Studies on the Effect of Ligands” ChemistrySelect, 8, e20230100, 2023. ( https://doi.org/10.1002/slct.202301003 ). (IF: 2.0307)

[7]   Singh, A.; Singh, S.; Ghosh, K.; Ahmed, N. “Oxidative cyclization reactions catalyzed by designed transition metal complexes: A new strategy for the synthesis of flavone, quinolones and benzofuran derivatives” Synthesis 55, A-M, 2023. ( https://doi.org/10.1055/s-0042-1751489 ). (IF: 3.4)

[8]   Chaudhary, V. K.; Singh, S.; Kumar, K.; Choudhury, A. R.; Ghosh, K. “Facile synthesis of benzoxazole derivatives by a multi-component reaction catalysed by copper complexes capable of generating phenoxyl radical complex” ''NJC. 47, 18995-19004, 2023.'' ( https://doi.org/10.1039/D3NJ03160H ). (IF: 3.925)

[9]   Singh, A.; Boro, B.; Maji, A.; Singh, O.; Singh, S.; Singh, U. P.; Ghosh, K. “Design and synthesis of dinuclear cobalt(II) complexes derived from strong π-acidic ligands: crystal structure and studies on oxidation of sp3 C-H bond” New J. Chem. 47, 8951-8959, 2023. ( https://doi.org/10.1039/D3NJ00128H ) (IF: 3.925)

[10] Navale, G. R.; Rana, A.; Saini, S.; Singh, S.; Chaudhary, V.; Roy, P.; Ghosh, K. An efficient fluorescence chemosensor for sensing Zn(II) ions and applications in cell imaging and detection of Zn(II) induced aggregation of PrP(106-126) peptide. ''J. Photochem. Photobiol. A, 441'', 114703, 2023. ( https://doi.org/10.1016/j.jphotochem.2023.114703 ) (IF: 5.14)

[11] Navale, G. R.; Singh, S.; Ghosh, K. "NO donors as the wonder molecules with therapeutic potential: Recent trends and future perspectives" ''Coord. Chem. Rev., 481'', 215052, 2023. ( https://doi.org/10.1016/j.ccr.2023.215052 ) (IF: 24.833),

[12] Naithani, S.; Goswami, N.; Singh, S.; Kumar, A.; Goswami, T.; Kumar, P.; Kumar, S.; Yadav, V.; Kumar, S. “Turn-on detection of Al3+ and Zn2+ ions by NSN donors probe: Reversibility, logic gates and DFT calculations” Analytical Methods, 15, 6021-6030, 2023. ( https://doi.org/10.1039/D3AY01534C ). (IF: 3.1)

[13] Saini, R.; Navale, G. R.; Agrawal, S.; Singh, S.; Sarkar, D.; Ghosh, K. “Studies of newly designed Palladium complexes on the inhibition amyloid β1-42 peptide aggregation”. ''Int. J. Biol. Macromol. 248'', 125847, 2023. ( https://doi.org/10.1016/j.ijbiomac.2023.125847 ) (IF: 8.025)

[14] Ratnam, A.; Kumari, S.; Singh, S.; Mawai, K.; Kumar, R.; Singh, U.P.; Ghosh, K. “Unprecedented cleavage of -N-N- bond of ligand and phenyl ring nitration during nitric oxide (NO) reactivity studies: New ruthenium nitrosyl complex and photoinduced liberation of NO” ''J. Coord. Chem., 75'', 2933-2943, 2023. ( https://doi.org/10.1080/00958972.2022.2141115 ). (IF: 1.751)

[15] Maji, A.; Singh, O.; Singh, S.; Mohanty, A.; Maji, P. K.; Ghosh, K. “Palladium-based Catalysts Supported by Unsymmetrical XYC-1 Type Pincer Ligands: C5 Arylation of Imidazoles and Synthesis of Octinacoxate Utilizing Mizoroki-Heck Reaction" Eur. J. Inorg. Chem., 2020, 1596–1611, 2020. ( https://doi.org/10.1002/ejic.202000211 ). (IF: 2.551).

[16] Maurya, MR.; Nandi, M.; Chaudhary, P.; Singh, S.; Avecilla, F.; Prasad, R.; Ghosh, K. “Synthesis, reactivity, catalytic, anticancer, and cytotoxicity of mononuclear oxido- and dioxo-vanadium(V) complexes” ''Inorg. Chem.'' 63, 714-729, 2023. ( https://doi.org/10.1021/acs.inorgchem.3c03665 ). (IF: 5.3)

[17] Singh, A.; Singh, O.; Maji, A.; Singh, S.; Singh, U. P.; Maji, P. K.; Ghosh, K. “Catalytic reduction of substituted nitro-aromatics through in-situ generated Co(0) nanoparticle from Co(II) complexes supported by pentadentate ligands” ''Mol. Catalysis 555,'' 113835, 2024. ( https://doi.org/10.1016/j.mcat.2024.113835 ). (IF: 4.6).

[18] Chaudhary, V. K.; Kukreti, P.; Sharma, K.; Kumar, K.; Singh, S.; Kumari, S.; Ghosh, K. “A sustainable strategic approach for N-alkylation of amines with activation of alcohols triggered via hydrogen auto-transfer reaction using Pd(II) complex: Evidences for metal-ligand cooperativity” Dalton Trans.55, 8740-8749, 2024. ( https://doi.org/10.1039/D4DT00864B ). (IF: 4.0).

Book chapters v  Kumar, S.; Singh, S.; Ghosh, K. "Ruthenium Nitrosyl Complexes: Photoinduced Delivery of Nitric Oxide (NO) to Different Biological Targets". Springer Nature, ISBN 978-3-031-24777-4, 2023 ( https://doi.org/10.1007/978-3-031-24778-1_21 ).