User:Samm42890/sandbox

Article Evaluation: (Model organism)


 * This article is part of four WikiProjects as a B-class, mid-important projects and yet has not had any significant discussions within the Talk tab or additions to the body of the article in several years.
 * Because of the importance of model organisms to health and medicine, the article should be evaluated by a health professional and should be held to the health and medicine standards set forth by Wikipedia.
 * The 107th reference is a link to a third party search engine. This should be replaced with a link to the actual NIH website SOP for Model Organisms.
 * There should be an addition of the explanation of homology in biology, or at least a link to the Wikipedia article.
 * The organization of the article feels poor, overall. I believe there should be a better title for each section and that this article could be expanded upon greatly.

Article Evaluation: (Drug resistance)


 * This article should be held to the health and medicine standards described by Wikipedia and so any edits will need to be well thought out.
 * With that said, despite the high importance that several projects have attributed to this article, it needs many edits and could be expanded greatly.
 * The last time anyone "talked" about this was in July of this year, but for the most part, not much change is occurring with this article.
 * Specifically, the words "arms race" seems inappropriate for this article.
 * The 23rd citation does not go to the correct source and is improperly formatted.Content Gaps in Drug resistance:

The article is missing or unorganized in many ways. There are separate articles within Wikipedia for drug tolerance, drug dependence, drug sensitization, and drug resistance, which is not ideal because there are so many overlapping topics within all of those articles and it is not easy to distinguish between them. The article is missing a better explanation on the mechanisms of drug resistance.

Contribution to article (Drug resistance):


 * 1) Change the titles of each of the overlapping articles so that they are more concise and help the reader navigate to the correct topic within Wikipedia. The new title of Drug resistance should become: Pathogen Resistance to Medications. The new title for drug tolerance should become: Human Body's Tolerance to Medications. The article drug dependence redirects to substance dependence and I don't think that article needs to be named differently because it will be too convoluted if its made longer.  The article drug sensitization redirects to the title Reverse Tolerance but I think it should go back to being drug sensitization because that is a better description. (The drug sensitization article is still a stub and needs more work than Drug resistance.)
 * 2) The beginning of each of the four articles should contain a link with small explanation for each separate article so that the reader knows where to go to find what they are looking for. In the Drug tolerance article, I would write; This article discusses microbe and cancer resistance to medications. To read about the human body's tolerance to medications, go to: drug tolerance. To read about substance dependence in humans, go to substance dependence. To learn about drug sensitization in humans, go to drug sensitization.
 * 3) The word "curing" in the first article should be changed to 'treating.'
 * 4) In humans, the gene ABCB1 encodes MDR1(p-glycoprotein) which is a key transporter of medications on the cellular level. If MDR1 is overexpressed, drug resistance increases.[ 35] Therefore, ABCB1 levels can be monitored. [ 35] In patients with high levels of ABCB1 expression, the use of secondary treatments, like metformin, have been used in conjunction with the primary drug treatment with some success. [ 35]

Drug resistance References:

References

Christian Ramos-Peñafiel, Irma Olarte-Carrillo, Rafael Cerón-Maldonado, Etta Rozen-Fuller, Juan Julio Kassack-Ipiña, Guillermo Meléndez-Mier, … Adolfo Martínez-Tovar. (2018). Effect of metformin on the survival of patients with ALL who express high levels of the ABCB1 drug resistance gene. Journal of Translational Medicine, Vol 16, Iss 1, Pp 1-9 (2018), (1), 1. https://doi.org/10.1186/s12967-018-1620-6 [ 35]

Duckenfield, J. (2013). Antibiotic Resistance Due to Modern Agricultural Practices: An Ethical Perspective. Journal of Agricultural & Environmental Ethics, 26(2), 333–350. https://doi.org/10.1007/s10806-011-9370-y

Wood, F., Simpson, S., & Butler, C. C. (2007). Socially responsible antibiotic choices in primary care: a qualitative study of GPs’ decisions to prescribe broad-spectrum and fluroquinolone antibiotics. Family practice, 24(5), 427-434.

Yi, G., Xiang, W., Feng, W., Chen, Z., Li, Y., Deng, S., … Liu, Y. (2018). Identification of Key Candidate Proteins and Pathways Associated with Temozolomide Resistance in Glioblastoma Based on Subcellular Proteomics and Bioinformatical Analysis. BioMed Research International, 1–12. https://doi.org/10.1155/2018/5238760

PEER REVIEW(Connor Sisk)

With an article with such heavy and medical vocabulary I think changing the articles titles is a great idea. It will help navigate the reader to more specific information they are looking for, rather than having to read through the entire article to find what they are looking for. I also think that focusing on the gene that transports the medications throughout the body should be discussed in detail, because without it medication would be unusable all together. In my opinion that is where it all starts, so your article should start with the gene ABCB1 going into detail with its role throughout our body, then going into what the medications are capable of doing. I like the change of "curing" into treating, it is a good use of vocabulary because obviously things don't always go according to plan in the medical industry.

Response to Peer Review:

Thank you for your thoughts Connor. I am glad you like my ideas and I will do my best to incorporate my changes into the article itself.

Contributions to article:

Several parts were removed due to redundancy or direct "copy and paste" portions that were not correctly cited.

Misspelled words were edited.

My explanation of a drug treatment was added under the Treatments section of the article.

A brief explanation of the article was added and the introduction itself was restructured.