User:Santamaria2012/Solanum anguivi saponins inhibit basal erythropoiesis in Rattus norvegicus

Solanum anguivi saponins inhibit basal erythropoiesis in Rattus norvegicus By Elekofehinti OO, Adanlawo IG, Fakoya A

The effect  of  saponin  purified  from  Solanium  anguivi  Lam. fruits on haematology  parameters  of  rats  (Rattus  novergicus)  was investigated. Thirty six (36) rats (Rattus novergicus) of average weight (125±  12g)  were  divided  into  six  (6)  groups  of  six  animals each  designated  as  A  (n=6,  2.0  ml  distilled  water),  B  (n=6,20mg/kg  saponin),  C  (n=6,  40mg/kg),  D  (n=6,  60mg/kg),  E  (n=6,80mg/kg),  and  F  (n=6,  100mg/kg). Saponin was  administered orally once daily to groups B, C, D, E and F for (21) days while group  A served as control. The animals were then sacrificed and blood was obtained for estimation of the data herein presented. Solanum anguivi  fruit  saponin  had  a  significant  reduction (P<0.05) in  red  blood cells  (RBC),  white blood cells  (WBC)  and Haemoglobin  (Hb)  concentration  and  the  decrease  was  dose dependent. There was  no  significant  difference  in  packed  cell volume (PCV),  basophil, lymphocyte  and  eosinophil. There was significant increase  in  neutrophil  at  100mg/kg  (P<0.05). The observed significant  reduction  in  RBC  and  Hb  concentration were  indication  of  defective  haematopoiesis  and  anaemia respectively. Therefore, saponins from  S.  anguivi  fruits  inhibit erythropoiesis.