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= Pulmonary Interstitial Glycogenosis = Pulmonary interstitial glycogenosis (PIG), also known as cellular interstitial pneumonia, is a rare lung disease that occurs in young infants. Although the main cause is unknown, it is generally found in neonatal with complicated pregnancy and infants with respiratory distress and cardiovascular disorders. The disease is thought to be the result of an abnormal growth in the lungs, triggering glycogen accumulation in the lungs and causing oxygen deficiency. Lung biopsy and histological examinations aid in diagnosing and corticosteroids therapy is commonly used in treatment. Although this method has been utilised favourably, the use of corticosteroids therapy has yet to be the official guideline of treatment due to the potential side effects.



Signs and symptoms
How as a result of an abnormal development in the lung, unrelating to inflammatory or reactive process, it triggers glycogen accumulation in the cell of the lungs.

Causes
Sudden onset of respiratory distress is frequently observed in infants with PIG and that complicated pregnancy is a cause of the disease.

Diagnosis
The author discusses in details of different ways to approach diagnosing this rare diseases, such as through genetic testing and imaging studies. However, he still states lung biopsy is still the option in most cases. Also, it is mentioned that infants will improve with steroid therapy, but prognosis is dependent on the type of lung growth abnormalities associated with PIG.