User:Saraj16/sandbox

On the Neuroinflammation page adding a "Spinal Cord Injury" section below the "Traumatic Brain Injury" making it the new section 5
Outline:

1) summarizes your article and says why it is important that it be accurate and updated

The neuroinflammation wikipedia article discusses the potential causes of neuroinflammation including traumatic brain injury, Multiple Sclerosis, Alzheimers, Parkinson's disease, and aging. It lacks a section on traumatic spinal cord injury section which is also involved neuroinflammation and is an important topic. This topic needs to be updated often because spinal cord injury is a developing field. Many of the papers I cited and used to write my part of the section were published between the last few years, so it's definitely a developing field. Also it is important for any wikipedia page to be updated because its a popular site and many people depend on, so it should be kept up to date and it should have the correct information.

2) name specifically which parts, sections, or paragraphs assigned to you.

I will write the first part of the spinal cord injury section, involving an introduction to the different types of injuries, the differences between primary and secondary injury, and some events associated with the inflammatory response.

3) summarize your plan or suggestions for improvement (i.e. discuss what to improve, not yet making the specific edits - just your plan for the instructor to review and give feedback.

Since I am working on writing an entirely new section I do not have suggestions for improvement of previous sections. My plan is to provide introductory information about spinal cord injury. I also plan on linking to other wikipedia pages involving macrophages as well as the spinal cord injury wikipedia page.

4) Create a section in your Sandbox titled "Bibliography" and compile a list of relevant, reliable books, journal articles, or other sources that you will use to support your work. Post that bibliography to the talk page of the article you'll be working on, and in your sandbox. Make sure to check in on the Talk page to see if anyone has advice on your bibliography.

Bibliography: Final Draft:

Spinal Cord Injury (SCI) can be divided into three separate phases. The primary or acute phase occurs from seconds to minutes post injury, the secondary phase occurs from minutes to weeks after injury, and the chronic phase occurs from months to years following injury. A primary SCI is caused by spinal cord compression or transection, leading to glutamate excitotoxicity, sodium and calcium ion imbalances, and free radical damage. Neurodegeneration via apoptosis and demyelination of neuronal cells causes inflammation at the injury site. This leads to a secondary SCI, whose symptoms include edema, cavitation of spinal parenchyma, reactive gliosis, and potentially permanent loss of function.

During the SCI induced inflammatory response, several pro-inflammatory cytokines including interleukin 1β (IL-1β), inducible Nitric Oxide Synthase (iNOS), Interferon-γ (IFN-γ), IL-6, IL-23, and tumor necrosis factor α (TNFα), which activates local microglia and attracts various immune cells such as naive bone-marrow derived macrophages. These activated microglia and macrophages play a role in the pathogenesis of SCI.

Notes/Edits:

- My contribution to the SCI section will be inserted first and Grace's contribution will come after

- I also wrote about scar formation, which occurs during the chronic SCI phase, but we removed information about the chronic phase because it seemed like a very small detail that did not fit in with the rest of our section. "It has also been reported that Periostin (POSTN), involved in heart, tooth, and bone development during early prenatal development and pericyte proliferation and scar formation during SCI, increases TNFα expression"

- You will notice that Grace's first paragraph and my second paragraph are identical. We both contributed to this paragraph as her paper discussed 1β (IL-1β) and TNFα and my paper discussed iNOS, IFN-y, IL-6, and IL-23.

-We also decided it would be wise to link to other wiki pages that go further in detail into SCI, macrophages, and some of the cytokines/chemokines mentioned if possible.

Bibliography: