User:Savina Shekerova/sandbox

International Metabolic Institute (IMI) is an organization that focuses its work on the issue of the Metabolic syndrome.

International Metabolic Institute
To provide the most appropriate and accurate solutions for the prevention of the problem, IMI works together with endocrinology institutes, metabolic diseases institutes, and with various research organizations. IMI processes and analyzes scientific studies in the field. It creates its own database of clinical trials and information for patients, in order to provide the most appropriate and accurate solutions for prevention of metabolic syndrome.

Metabolic Syndrome
According to the World Health Organization, high serum triglyceride level, low serum high-density lipoprotein cholesterol, hypertension, and elevated fasting blood glucose are four of the five risk factors (three out of the five required) for the diagnosis of metabolic syndrome. Metabolic syndrome is associated with subclinical low grade inflammation, oxidative stress, and intestinal dysbiosis and it has been suggested that the gut microbiota could be a target for nutraceuticals. In this regard, some medicinal mushrooms (reishi, shiitake,maitake, lion’s mane) vitamins and super green foods (Arthrospira platensis, Salvia officinalis, Camellia sinensis, Chlorella vulgaris) could help in prevention of metabolic sybdrome.

Mission
The scientists in International Metabolic Institute believe that people with metabolic syndrome deserve appropriate solution for their specific situation. Because of that the institute focuses on providing quality and reliable help.

The main purpose of the International Metabolic Institute is to improve the quality of life of people suffering from metabolic syndrome. In order to achieve that, the institute works constantly on discovering and delivering solutions for reducing the risk of complications related to that kind of syndrome.

Products
The specialists in the IMI continuously develop and change their product in accordance with the latest researches in the field. The accurate data analysis and scientific validation provide quality and ongoing patient support.

The academics in IMI study and develop products that reduce the risk of metabolic syndrome consisting all natural ingredients such as healing eastern mushrooms Reishi, Shiitake, Maitake. Those are proven to provide numerous health and cardiovascular benefits for the body.

Reishi
Ganoderma lucidum (Reishi) is a wood-degrading basidiomycete which has been used extensively as "the mushroom of immortality" in China, Japan, Korea and other Asian countries for 2000 years. The mushroom extract demonstrates numerous pharmacological effects. The basidiocarp, mycelia and spores of Ganoderma lucidum contain approximately 400 different bioactive compounds, which mainly include triterpenoids, polysaccharides, nucleotides, sterols, steroids, fatty acids, proteins/peptides and trace elements which has been reported to have a number of pharmacological effects including immunomodulation, anti-atherosclerotic, anti-inflammatory, analgesic, chemo-preventive, antitumor, chemo and radio protective, sleep promoting, antibacterial, antiviral (including anti-HIV), hypolipidemic, anti-fibrotic, hepatoprotective, anti-diabetic, anti-androgenic, anti-angiogenic, anti-herpetic, antioxidative and radical-scavenging, anti-aging, hypoglycemic, estrogenic activity and anti-ulcer properties. Ganoderma lucidum has now become recognized as an alternative adjuvant in the treatment of leukemia, carcinoma, hepatitis and diabetes.

Shiitake
Shiitake is widely used in addition to the therapies against: cancer; diabetes; allergies; fungal infections; diseases of the Immune System (including AIDS); Flu and cold; Upper respiratory tract infections; Cardiovascular diseases and others.

The immunostimulatory activity of Shiitake is due to the unique polysaccharide Lentinan. Like Reishi, Shiitek's immunostimulatory activity is directly related to its antitumor function. The carcinomatostatic effect of lentinan is the result of activation of the host immune system, namely β-D-glucan binds to receptors located on lymphocyte surfaces or to serum specific proteins that activate cytotoxic macrophages, NK cells and other effector cells. They all increase secretion of antibodies, such as interleukins (IL-1, IL-2) and interferon (IFN-γ). In vitro and in vivo studies demonstrate that lentinan activates the expression of MHC II, CD80 / CD86 and Toll-like receptors (TLR2 / TLR4) involved in the immune response. Lentinan causes a cascade of reactions leading to the activation of an immune response, while serving as a bridge that coordinates the activation of innate and acquired immunity. Lentinan suppresses the synthesis of prostaglandins and immunosuppressive substances that inhibit T-cell differentiation in humans and animals.

Maitake
Numerous studies involving biologically active molecules isolated from the healing mushroom Maitake confirm its positive effects on immune system functions. Maitake promotes activation of macrophages and activates various other cells, such as natural killers (NK) and cytotoxic T-cells (TC), which are the major defense against cancerous and virus-infected cells. Maitake increases secretion of interleukin-1, interleukin-2, and lymphokines. The end of this cascade is increased protection against infections, AIDS and cancer. The polysaccharide D-fraction of Maitake has a pronounced anti-tumor effect represented by tumor growth inhibition, localized in the colon, lung, stomach, liver, prostate, brain and other organs.

Researchers have identified several mechanisms through which Maitake counteracts carcinogenesis           :
 * Protect the transformation of healthy cells into cancer cells
 * Prevention of metastasis.
 * By slowing or stopping the growth of tumors.

Coenzyme Q10
Coenzyme Q10 (CoQ10) is a substance similar to a vitamin. It is found in every cell of the body. Your body makes CoQ10, and your cells use it to produce energy your body needs for cell growth and maintenance. It also functions as an antioxidant, which protects the body from damage caused by harmful molecules. CoQ10 is naturally present in small amounts in a wide variety of foods, but levels are particularly high in organ meats such as heart, liver, and kidney, as well as beef, soy oil, sardines, mackerel, and peanuts.

Coenzyme Q10 is beneficial for heart health in many ways. It assists in maintaining the normal oxidative state of LDL cholesterol, helps assure circulatory health, and supports optimal functioning of the heart muscle. CoQ10 may also help support the health of vessel walls.

Many claims are made about CoQ10. It is said to help heart failure, as well as cancer, muscular dystrophy, and periodontal disease. It is also said to boost energy and speed recovery from exercise. Some people take it to help reduce the effects certain medicines can have on the heart, muscles, and other organs.
 * What is CoQ10 used for?

Conjugated linoleic acid
Conjugated linoleic acid (CLA) is a potent anti-oxidant, anti-carcinogen, and anti-catabolite, as well as a powerful immune system enhancer. Some of the common accolades of CLA are assistance in fat burning, building and retention of lean muscle, and is a cancer fighter.

Taking conjugated linoleic acid along with ramipril seems to reduce blood pressure more than ramipril alone in people with uncontrolled high blood pressure. Taking conjugated linoleic acid by mouth daily might help decrease body fat in adults, but it does not seem to decrease body weight or body mass index (BMI) in most people. Conjugated linoleic acid might reduce feelings of hunger, but it’s not clear if this leads to reduced caloric intake. While conjugated linoleic acid might help reduce body weight, some research shows that taking a particular form of conjugated linoleic acid might increase risk factors for type 2 diabetes and heart disease.

Some of the most known suggested benefits of CLA supplementation include:
 * Increased metabolic rate
 * Enhanced muscle growth
 * Lowers cholesterol and triglyceride
 * Lowers cholesterol and triglyceride


 * Lowers insulin resistance


 * Reduces food-induced allergic reactions

Red Yeast Rice
This type of rice has various amounts of naturally occurring substances called monacolines. Monacolin K also known as lovastatin or mevinolin with LDL (low density lipoprotein) cholesterol lowering properties - is the main monacolin in Monascus purpureus-fermented rice (75-90 % of total monacolin content).

There are also other active ingredients in red yeast rice that may affect blood cholesterol including sterols (beta-sitosterol, campesterol, stigmasterol, sapogenin), isoflavones, and monounsaturated fatty acids.

Generations of Chinese have taken red yeast rice to soothe upset stomach, diarrhea and indigestion. Improved circulation of blood is one of the potential benefits of taking red yeast rice, though there have been no in-depth studies conducted to prove this claim, according to Medline Plus of the National Institutes of Health.

Melatonin
Melatonin is a hormone made by the pineal gland, a small gland in the brain. Melatonin helps control your sleep and wake cycles. Very small amounts of it are found in foods such as meats, grains, fruits, and vegetables. You can also buy it as a supplement.

Your body has its own internal clock that controls your natural cycle of sleeping and waking hours. In part, your body clock controls how much melatonin your body makes. Normally, melatonin levels begin to rise in the mid- to late evening, remain high for most of the night, and then drop in the early morning hours.

Light affects how much melatonin your body produces. During the shorter days of the winter months, your body may produce melatonin either earlier or later in the day than usual. This change can lead to symptoms of seasonal affective disorder (SAD), or winter depression. Natural melatonin levels slowly drop with age. Some older adults make very small amounts of it or none at all.

L-Carnitine
L-carnitine is an amino acid (a building block for proteins) that is naturally produced in the body. L-carnitine is used for conditions of the heart and blood vessels including heart-related chest pain, congestive heart failure (CHF), heart complications of a disease called diphtheria, heart attack, leg pain caused by circulation problems (intermittent claudication), and high cholesterol. Some people use L-carnitine for muscle disorders associated with certain AIDS medications, difficulty fathering a child (male infertility). L-carnitine helps the body produce energy. It is important for heart and brain function, muscle movement, and many other body processes.

Acetyl-L-Carnitine supplementation is also a very safe method of improving insulin sensitivity and blood vessel health, particularly for people with delicate or weakened cardiac health.

Omega-3 fatty acids
Omega-3 fatty acids are incredibly important.They are a family of polyunsaturated fats that we must get from the diet. They can have all sorts of powerful health benefits for your body and brain.

Prediabetes means that your blood sugar level is higher than normal but not yet high enough to be type 2 diabetes. Without lifestyle changes, people with prediabetes are very likely to progress to type 2 diabetes. There's good news, however. Progression from prediabetes to type 2 diabetes isn't inevitable. Eating healthy foods, incorporating physical activity in your daily routine, maintaining a healthy weight and getting enough sleep can help bring your blood sugar level back to normal.

Omega-3 fatty acids:
 * Can Fight Depression and Anxiety


 * Improve Eye Health
 * Are crucial for brain growth and development
 * Can Improve Risk Factors For Heart Disease
 * Can Reduce Symptoms of ADHD
 * Can Reduce Symptoms of Metabolic Syndrom
 * Can Fight Inflammation
 * Can Fight Autoimmune Diseases
 * Can Fight Age-Related Mental Decline
 * Can Reduce Fat in The Liver
 * May Improve Bone and Joint Health
 * May Improve Sleep
 * Are Good For Your Skin

=Activities of IMI=
 * Constant gathering of information from different scientific sources
 * Development of products that reduce the risk of complications caused by metabolic syndrome
 * Internal and external validation