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Mary Jane Santa Ana Guck (October 21, 1963 – March 2, 2024), known professionally as Jaclyn Jose, was a Filipino actress. Known for her work in dramas and her portrayals of antagonists, she was a recipient of various accolades, including a Cannes Film Festival Award, five Gawad Urians, two Luna Awards, and a FAMAS Award, in addition to an Asian Film Awards nomination.

Jose made her acting debut in 1984 in William Pascual's Chicas and Chito S. Roño's Private Show, earning her first FAMAS Awards nomination for the latter. The following year, she starred in Lino Brocka's White Slavery, which earned her her first Gawad Urian nomination. Her first Gawad Urian win came from her role in the adult drama film Takaw Tukso (1986), winning the Best Actress award. She won her first Luna Award for Best Supporting Actress in 1996 for playing the mistress of Flor Contemplacion's husband in The Flor Contemplacion Story (1995), for which also earned her her fourth Gawad Urian and fourth FAMAS Award nomination. She continued to gain awards and critical acclaim for her film works from 1990s through 2000s.

Jose made her television debut in Familia Zaragoza (1996–1997) and gained wider recognition with a supporting role in Mula sa Puso (1997–1998). She later appeared in numerous soap operas including Nagsimula sa Puso (2009), Reputasyon (2011–2012), Kahit Puso'y Masugatan (2012–2013), as well as on television series including action drama Zorro (2009), period drama Ilustrado (2014), sports drama Bolera (2022), and action drama Batang Quiapo (2023).

She then gained international recognition for playing the role of a matriarch with underground meth business in Brillante Mendoza's Ma' Rosa (2016), which was the Philippine submission for Best International Feature Film at the 89th Academy Awards; she subsequently earned the Cannes Film Festival Award for Best Actress.

Early life and career beginnings: 1963–1994
Mary Jane Santa Ana Guck was born on October 21, 1963 in Angeles, Pampanga. She was raised by her mother, Rosalinda Sta. Ana, who has performed in zarzuelas. At age four, her parents were separated. She has a half-sister, Veronica Jones, who is a former actress. Jose planned to go to Japan to pursue a singing career, however, she stated that she would have a hard time taking care of her family if she goes there. She later worked as her sister Veronica's personal assistant and was recommended by director William Pascual to become an actress, where she was given the screen name Jacklyn Jose.

Jose began her career in the film Chicas (1984). In 1985, she had a starring role in Escort Girls She also played in Lino Brocka's White Slavery; her performance was lauded by critics and was nominated for a Gawad Urian. In 1986, she made her theater debut in Joel Lamangan's Woman, playing the wife of a rebellious man.

Established actress: 1995–2015
Jose first starred in her first television series Familia Zaragoza in 1995. She then gained wider recognition with a supporting role in Mula sa Puso.

International recognition and final years: 2016–2024
Jose's international breakthrough came in 2016 where she starred in Brillante Mendoza's Ma' Rosa, which premiered at the 2016 Cannes Film Festival. She played the role of a mother who sells drugs but was caught in a corruption by the police. Jose won the Cannes Film Festival Award for Best Actress. The film was yhe Philippine submission for the Best International Feature Film at the 89th Academy Awards. Jose's most recent acting role is in the primetime action drama series FPJ's Batang Quiapo, based on the 1986 film of the same name. She played Dolores Espinas, a chief who works at a prison where Coco Martin's character is imprisoned. She will posthumously star in the upcoming series Sellblock.

Death and legacy
Jose died of a heart attack on March 2, 2024 at age 60. Her death was confirmed two days later by both talent agency PPL Entertainment, as well as by her daughter Andi Eigenmann.