User:ScienceSalamander/sandbox

The Patient-Derived Models Repository (PDMR) is a National Cancer Institute (NCI/NIH) sponsored resource comprising patient-derived tumor xenografts (PDTXs, PDXs) and in vitro patient-derived cell cultures (PDCs). As part of the NCI precision oncology initiativeSM, the PDMR provides a diverse collection of well-characterized xenograft models to both public and private research organizations to enhance drug discovery efforts. The stated aim of the repository is to assemble 1000 models, where 75-100 unique patients are included per common cancer type and considerable effort is expended deriving models for less prevalent diseases (e.g. Small cell lung cancer) Available reagents include (but are not limited to); tumor fragments, early-passage cell lines, and cancer-associated fibroblasts (CAFs). In addition, RNA, DNA, and protein are available for investigator-directed molecular analysis. Each model is accompanied by a data package that includes; available clinical information, histopathology, STR profiling, human pathogen testing, growth kinetics and molecular profiling (Next-Generation Sequencing). A web portal (www.PDMR.cancer.gov) is used to search available data and make requests for specific biological samples.