User:Sedavis1996/sandbox

The expression of BDNF can be affected by different epigenetic modifications, and BDNF promoters can be individually regulated by different epigenetic alterations. /Epigenetics of depression

The hippocampus also experiences a number of histone methylation changes: H3K27-trimethylation is hypomethylated in response to stress, while H3K9-trimethylation and H3K4-trimethylation are hypermethylated in response to short term stress. However, H3K9-trimethylation and H3K4-trimethylation can be hypomethylated in response to chronic, long term stress