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Hello, Wikiers! My real life name is Jin Xi. I'm a virologist. Here is my academic home page http://scholar.google.de/citations?user=loNx8OMAAAAJ&hl=en.

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巨型核质DNA病毒,英文: Nucleocytoplasmic Large DNA viruses 简称 NCLDV 由一类真核生物DNA病毒科组成,包括:


 * 1) 非洲豬瘟病毒科
 * 2) 囊泡病毒科
 * 3) 虹彩病毒科
 * 4) 马赛病毒科
 * 5) 巨型病毒科
 * 6) Mimiviridae
 * 7) 藻类DNA病毒科
 * 8) 潘多拉病毒科
 * 9) Pithoviridae
 * 10) 痘病毒科

All have both common and unique features of genomic DNA and virion structure. It remains uncertain whether the similarities of different families of this grouping of NCLDV are due to independent recruitment of the same or related host genes during viral replication or whether they simply share a common viral ancestor, although the latter theory is controversial and under heavy scrutiny.[1]

There are 47 NCLDVs core genes currently recognised. These include the four key proteins involved in DNA replication and repair. These include the enzymes DNA polymerase family B, the topoisomerase II A, the FLAP endonuclease and the processing factor proliferating cell nuclear antigen. Other proteins include the DNA dependent RNA polymerase II and transcription factor II B.

It is probable that these viruses evolved before the separation of eukaryotes into the extant crown groups. The ancestral genome was complex with at least 41 genes, including: (1) the replication machinery; (2) up to four RNA polymerase subunits; (3) at least three transcription factors; (4) capping and polyadenylation enzymes; (5) the DNA packaging apparatus; (6) structural components of an icosahedral capsid and the viral membrane. 所有有基因组DNA和病毒粒子结构的两个常见的和独特的功能. 它仍然不明朗不同科的NCLDV这个分组的相似性是否是由于在病毒复制，还是他们只是有着共同的祖先病毒相同或相关的宿主基因自主招生，尽管后者的理论是有争议的，在重审查. [1]

目前公认的47 NCLDVs核心基因. 这些措施包括参与DNA复制和修复的四个关键蛋白. 这些措施包括酶DNA聚合酶家族B ，拓扑异构酶ⅡA，皮瓣内切酶和处理因素增殖细胞核抗原. 其他蛋白质包括DNA依赖性RNA聚合酶Ⅱ和转录因子ⅡB.

这是可能的，这些病毒真核细胞分离成现存冠组之前演变. 祖传的基因很复杂，至少41个基因，其中包括： （ 1）复制机制; （ 2 ）最多四个RNA聚合酶亚基; （ 3 ）至少有三个转录因子; （ 4 ）封盖和多聚腺苷酸酶; （ 5 ） DNA的包装装置（6）的二十面体衣壳和病毒膜的结构部件.