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Treatment
The Picardy sweat disease was previously believed to arise from a leaven or a poison that would directly contaminate the blood. Due to this, physicians during this time suggested expelling the disease through sudorifics, cordials, ptisans, and heavy bedclothes. Sudorifics were suggested because they are medicines that induce sweating. Sweating would then allow the disease-causing agent to have the ability to exit the blood via the sweat glands. Heavy bedclothes were proposed because they would also induce sweating, thus resulting in the expulsion of the disease while the infected patient was asleep. Drinking cordials was presented to infected individuals because cordials were believed to sterilize the body and blood due to the low alcohol content found in cordials. Additionally, ptisans, or warm teas, were recommended in hopes that the herbs within the ptisan would have healing agents that would aid in the expulsion of the disease.

Around 1773, the treatments for the Picardy sweat disease changed when other means of curing the disease were introduced. Venesection procedures, mild lukewarm drinks, small doses of hypnotic medicine, and withdrawing practices on the hands and feet were suggested as more efficient ways of treating the Picardy sweat disease. Venesection procedures, or more commonly known today as phlebotomy procedures, would directly remove blood from the body and essentially the disease along with it. The blood is drawn through a small incision or a puncture of the skin. Venesection would have been most efficient in the early stages of infection before the disease has had the opportunity to spread throughout the body. Mild lukewarm drinks were opposite of the warm ptisans that were suggested prior to 1773. Hypnotic medicines were suggested to aid in sleeping and provide some relief during the night. Withdrawing practices on the hands and feet were performed to generate rashes, which usually soothed the pains of the disease. An example of how they did this includes bathing the hands and feet in mustard water which irritates the area, therefore, drawing blood and disease to those regions of the body. Essentially, the goal of this was to intensify pain in particular regions of the body by inducing rashes to make the pain caused by Picardy sweat disease feel less extreme. Counter-irritation was important for providing relief and was especially necessary when the lungs or head became congested.

Another treatment for the Picardy sweat disease during this time was quinine sulfate. Physicians would prescribe doses of 3 grams or less of quinine sulfate to affected patients. Quinine sulfate was later used as a treatment against a disease caused by parasites called malaria. This disease typically enters the body via the bloodstream due to mosquito bites from parasites carrying the malaria disease. This disease is similar to that of the Picardy sweat disease because both pathogens enter the human body by infiltrating the bloodstream. Quinine sulfate was a suggested form of treatment because it was assumed to expel the disease through the drug's side effects. Quinine sulfate can be responsible for inducing sweating and causing easy bleeding. These side effects would fundamentally expel the disease from the human body.