User:Seppi333/sandbox2

Reference for the NAcc article on neurotransmitter cell types (D1-type & D2-type NAcc MSNs; GABAergic & cholinergic interneurons; and, GABAergic projection MSNs) - http://perspectivesinmedicine.cshlp.org/content/2/10/a011957.full

Incomplete table
Need to wait for further research on subregion+subtype-specific cognitive functions to be published before finishing this table and adding it to nucleus accumbens.


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ΔFosB, addiction, ADHD, neural projections, etc

 * Complete set of brain structures that constitute the addiction system (need to determine neural pathways + primary pathway neurotransmitters that connect these structures):
 * "Studies have shown that cravings are underpinned by activation of the reward and motivation circuits (McBride et al., 2006, Wang et al., 2007, Wing et al., 2012, Goldman et al., 2013, Jansen et al., 2013 and Volkow et al., 2013). According to these authors, the main neural structures involved are: the nucleus accumbens, dorsal striatum, orbitofrontal cortex, anterior cingulate cortex, dorsolateral prefrontal cortex (DLPFC), amygdala, hippocampus and insula." - quote from linked review
 * Medial PFC ←→ Basolateral amygdala - bidirectional glutamatergic projections (http://www.jneurosci.org/content/25/32/7429.full) [pathway impaired by stims]
 * Basolateral amygdala → Medial PFC - minor GABAergic interneuron projection (http://www.jneurosci.org/content/25/32/7429.full) [pathway impaired by stims]
 * Basolateral amygdala → Central medial amygdala - glutamatergic projection (http://www.jneurosci.org/content/25/32/7429.full)
 * Large series of these connections listed in this figure caption (+in the paper): http://perspectivesinmedicine.cshlp.org/content/2/10/a011957/F1.expansion.html


 * ∆FosB: A transcriptional regulator of stress and antidepressant responses
 * Fluoxetine epigenetically alters the CaMKIIα promoter in nucleus accumbens to regulate ΔFosB binding and antidepressant effects

Random papers:


 * PMID 23085449
 * PMID 22484409
 * PMID 22013150
 * PMID 23576888
 * PMID 24354721
 * PMID 24382886


 * DeltaFosB Isoforms induction graph
 * DeltaFosB Isoforms induction graph
 * DeltaFosB Isoforms induction graph