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Administration
Lurasidone should be administered orally with food (> 350 calories). Studies have shown that when Lurasidone is taken with food absorption increases.

Contraindications
Lurasidone is contraindicated in individuals who are taking strong CYP3A4 inhibitors (ketoconazole, clarithromycin, ritonavir, etc.) or inducers (carbamazepine, St. John’s wort, phenytoin, rifampin etc.) .The use of Lurasidone in pregnant women has not been studied and is not recommended. If a pregnant woman is taking Lurasidone the physician should evaluate the risk vs benefits. Excretion in breast milk is also unknown and not recommended. Additionally as with other antidepressants, Lurasidone increases the risk of suicidal thinking and behavior in patients 18 to 24 years old. In the United States Lurasidone is not indicated for use in children.