User:Sfiore315/sandbox

Lead section: Kisspeptin consists of a group of ligands for a G-protein coupled receptor. It has various functions in humans and animals. One such effect is found by disrupting the GPR54 signaling and causing hypogonadotrophic hypogonadism in rodents and man The Kiss1 gene is located on chromosome 1. It is transcribed in the brain, adrenal gland, and pancreas. Kisspeptin is required to initiate puberty. The kisspeptin system has a key role when considering the onset of puberty and reproduction showing that there is major stimulatory action on gonadotropin releasing hormone (GNRH). The release is due to an action on the anterior pituitary and also involves the release of luteinizing hormone (LH), and follicle stimulating hormone (FSH). These gonadotropic hormones lead to sexual maturation and gametogenesis.

Outline: Genomics: encoded in the kiss1 gene Sources: Hippocampal Dentate Gyrus, Adrenal gland, Pancreas Structure: 7 transmembrane protein Pathway: GnRH release Receptor: GPR54 Biological function: Role in puberty, Role in tumor suppression, Role in reproduction, Role in kidney function History of research References External links