User:Shermanmccarthy/Bisphenol S

Article Draft
Cancer

There is evidence to suggest that BPA-S has a direct link to teratogenic effects to vital organs such as the heart and liver. Additionally, BPA-S inhibits the expression of genes within the liver used for the metabolism thus leading to increased stress of the liver. https://pubs.acs.org/doi/pdf/10.1021/acs.est.7b03283

BPS has more effect on the reproductive system than other members of the bisphenol family.

Additionally, there is evidence to suggest that embryos with high levels of BPS exhibit teratogenic effects of vital organs such as the heart and liver. Additionally, BPS inhibits the expression of genes within the liver used for the metabolism thus leading to increased stress of the liver through the zebrafish life. Adult zebrafish that are exposed to high levels of BPS during development display hyperactivity due to an exponential increase in neural activity within the hypothalamus.

Zebrafish and humans share 70% of the same genes during development thus, they are a useful model organism to understand the effects of BPAS. Studies in the Zebrafish model have shown that parental exposure to BPS causes disrupted thyroid hormone levels in both the parental generation and F1 generation. Fetal exposure to BPS through the placenta, during a critical period, can have negative effects on the developmental programming of the fetus. Additionally, there is evidence to suggest that embryos with high levels of BPS exhibit teratogenic effects of vital organs such as the heart and liver. Additionally, BPS inhibits the expression of genes within the liver used for the metabolism thus leading to increased stress of the liver through the zebrafish life. Adult zebrafish that are exposed to low levels of BPS during development display hyperactivity due to an exponential increase in neural activity within the hypothalamus.

Cancer
Bisphenol-S has been linked to causing changes in the expression of genes associated with estrogen