User:Shrinwanti Ghosh/Goitre

Name of article: Goitre

 * Goitre is very dangerous disorder due to dysfunction of thyroid gland. People often neglect this. There should be awareness and early detect can save many lives.

Lead

 * The article specifies the location and the primary symptoms of this disorder in the introduction sentence itself.
 * The lead paragraph misses the description of the article's major section. The reader might not get the point what the reason behind the development of "Goitre".
 * It's explained in detail in content section whatever they have mentioned in Lead.
 * Lead is very concise.

Content

 * The entire article is relevant to the topic.
 * Few molecular related information are missing in this article. But the information what have been provided are up-to-date.
 * From the molecular biology point of view, this article is very narrow and the therapy is not mentioned in detail.
 * The article presented the historical data of the disease as it has spread over the years.

Tone and Balance

 * I feel the article is neutral.
 * The article is not biased.
 * Treatment section is under-represented.
 * This article is completely focusing on it's subject, thyroid disorder Goitre.

Sources and References

 * We can use this article as a reliable secondary source of information.
 * Though I feel the topic is explained well, I don't believe there is thorough detail.
 * The majority of sources to prove the topic are not very current.
 * Are the sources written by a diverse spectrum of authors? Do they include historically marginalized individuals where possible?
 * The links are accessible and referenced to proper page.

Organization

 * It's very easy to read and understandable.
 * There is no such major grammatical mistakes.
 * The article is well-organized and segregated into 7 specific sections.

Images and Media

 * The image provided are clear and very much relevant.
 * The images are captioned properly.
 * Images are maintaining copyright protection.

Checking the talk page

 * The Talk page represents different types of discussions like the type of Goitre, the treatment of it etc.
 * It's a Wikimedia project.

Overall impressions

 * This is good to consider as an introductory article about Goitre. But to gain detailed knowledge it's not the article to recommend as it does not have sufficient scientific information.
 * If some molecular or immunology related information could have been provided, it might be considered a good scientific article.
 * I think this is underdeveloped as it lacks scientific detailed information.

Overall evaluation

 * Link to feedback: Talk:Goitre

Thyroid Hormone Receptor
The thyroid hormone receptors, TRα1, TRβ1 are members of the nuclear receptor superfamily. THR mediate the action of thyroid hormone signaling in tissues to modulate physiological and developmental approaches.Within the nucleus, TRα1 and TRβ1 bind to the target genes, for influencing cellular processes, like cell proliferation, oxygen consumption, protein synthesis and metabolism.