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WDR90 is a protein that in humans is encoded by the WDR90 gene (16p13.3.). Orthologs of this gene have been found in nature from mammals to protazoa and everywhere in betweem. WDR90 multiple WD transducin repeating domains that have been found to play a role in a variety of function ranging from signal transduction and transcription regulation to cell cycle control, autophagy and apoptosis. This domain is conserved across the "ortholog space' Although there is no confirmed function of WDR90, through analyzing expression and experimental data, it is predicted that WDR90 is a hepatocellular carcinoma and cell proliferation.

Locus
The human gene WDR90 is found on chromosome 16 at the band 16p13.3.



There are a few known isoforms because the gene has 41 exons.

Aliases
This gene has several known aliases that include C16orf15-19 as well as KIAA1924, and WD repeat domain 90.

Paralogs

 * There is one known paralog for WDR90, it is called WDR16

Orthologs

 * The ortholog space of WDR90 is fairly large. It has been found in protozoa and mammals alike.

Primary sequence
The gene encodes a protein also called WDR90. The length of the mRNA sequence for this gene is 5250 base pairs, while the number of protein coding base pairs is 1750. The coding protein has a predicted molecular weight of 187.7 kDal. This protein is leucine, valine, and alanine rich and asparagine and methionine poor when compared to other human proteins.

Domains and motifs
WDR90 contains one characterized domain of unknown function called DUF667, as well as 19 WD repeat domains.

Post-translational modifications
Software predicted sites for post-translational modifications, but none of the results can be validated beyond computer predictions.

Secondary Structure
WDR90 is predicted to have one transmembrane region that spans 23 amino acids. The WD40 repeat family is known to adopt a 7-bladed beta-propeller fold, and this was repeated through the predictive computing of Phyre2, JSmol, and SWISS-MODEL.