User:Sikder redoan

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ACE IN HIBITOR DRUG The renin-angiotensin-aldosterone system (RAAS) Main article: Renin-angiotensin system Renin-angiotensin-aldosterone system One mechanism for maintaining the blood pressure is the release of a protein called renin from cells in the kidney (specifically: the juxtaglomerular apparatus). This produces another protein called angiotensin which signals the adrenal gland to produce a hormone called aldosterone. This system is activated in response to a fall in blood pressure (hypotension) as well as markers of problems with the salt-water balance of the body, such as decreased sodium concentration in a part of the kidney known as the distal tubule, decreased blood volume and stimulation of the kidney by the sympathetic nervous system. In such a situation, the kidneys release renin which acts as an enzyme and cuts off all but the first 10 amino-acid residues of angiotensinogen (a protein made in the liver, and which circulates in the blood). These 10 residues are then known as angiotensin I. Angiotensin I is then converted to angiotensin II by angiotensin converting enzyme (ACE) which removes a further 2 residues and is found in the pulmonary circulation as