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In Little Women, Alcott based her heroine "Jo" on herself. But whereas Jo marries at the end of the story, Alcott remained single throughout her life. She explained her "spinsterhood" in an interview with Louise Chandler Moulton, "I am more than half-persuaded that I am a man's soul put by some freak of nature into a woman's body. … because I have fallen in love with so many pretty girls and never once the least bit with any man.” However, Alcott's romance while in Europe with the young Polish man Ladislas "Laddie" Wisniewski was detailed in her journals but then deleted by Alcott herself before her death. Alcott identified Laddie as the model for Laurie in Little Women. Likewise, every character seems to be paralleled to some extent, from Beth's death mirroring Lizzie's to Jo's rivalry with the youngest, Amy, as Alcott felt a sort of rivalry for (Abigail) May, at times. Though Alcott never married, she did take in May's daughter, Louisa, after May's untimely death in 1879, caring for little "Lulu" for the next eight years.

In addition to drawing on her own life during the development of Little Women, Alcott also took influence from several of her earlier works including "The Sisters' Trial," "A Modern Cinderella," and "In the Garret." The characters within these short stories and poems, in addition to Alcott's own family and relationships, inspired the general concepts and bases for many of the characters within Little Women as well as the author's subsequent novels.

Little Women was well-received, with critics and audiences finding it suitable for many age groups. A reviewer of Eclectic Magazine called it "the very best of books to reach the hearts of the young of any age from six to sixty". It was a fresh, natural representation of daily life. With the success of Little Women, Alcott shied away from the attention and would sometimes act as a servant when fans would come to her house.