User:Sintegral/Opioid use disorder/AnonymousSphinx Peer Review

General info

 * Whose work are you reviewing?

Sintegral


 * Link to draft you're reviewing
 * User:Sintegral/sandbox


 * Link to the current version of the article (if it exists)
 * Opioid use disorder

Evaluate the drafted changes
(Compose a detailed peer review here, considering each of the key aspects listed above if it is relevant. Consider the guiding questions, and check out the examples of what feedback looks like.)

Review of your edits:

The image added is very beneficial, as a visual learner, this helps me understand what is being discussed in the text. The lines you added on the Suboxone strip: "In order to reduce the harm associated with buprenorphine injection, it is available in a sublingual formulation that combines buprenorphine with the opioid antagonist naloxone in a 4:1 ratio.This sublingual formulation is commonly administered as a film." are pretty clear and concise, I believe these to be good additions to the article. The additions also fit well in the organization of the article. However, I believe you should add 1 or 2 references to support the additions and add a space in between the sentences: "...ratio. This...". I also feel that you should make a note in the text that Suboxone is a mix of Buprenorphine and Naloxone, I can see the note of it in the added image's caption, but I feel it should be clear in the text as well. As someone who doesn't know much about Suboxone besides the fact that it exists and is related to drug usage, the text seems to imply that Suboxone is a small, thin transparent or opaque strip administered sublingually, the text mentions "sublingual...administered as a film", but I would like more of a description. The exact look of the strip, shape, general measurements, color, etc would be helpful as a reader as the text and image leave me a bit curious on what it really looks like, albeit giving me a general idea such as with the dosage measurement. This is more of a minor addition. The sentence: "This sublingual formulation is commonly administered as a film." seems to imply that there are other ways for Suboxone to be administered, are there? if so, what are they? I would assume via injection, but the text could be more clear.

What does "agonist/antagonist" mean in context of opioid replacement therapy? I would assume that it means "works against" or something similar, but a brief explanation near the first mention of it (first small paragraph of Opioid replacement therapy section) would be helpful.

The sentence: "As a partial agonist with high receptor affinity and modest efficacy, many buprenorphine effects plateau after approximately 16 mg, although doses of up to 32 mg are used clinically." is directly from the reference (22, https://www.tandfonline.com/doi/full/10.1080/10550887.2012.694598 ), which states: "In addition, as a partial agonist with high receptor affinity and modest efficacy, many of buprenorphine's effects plateau after approximately 16 mg, although doses of up to 32 mg are used clinically. ^84". The direct usage of this line is plagiarism. The line after it: "Thus, while it may induce euphoria similar to methadone in non-tolerate opiate addicts, attempts to increase this effect or achieve intoxication through dose escalation beyond this 32 mg ceiling are of little success" is very close to the line from the same reference: "Thus, although it may have similar rewarding properties as methadone in nontolerant opiate addicts, attempts to increase this effect or achieve intoxication through dose escalation beyond this ceiling are of little avail ^85", though there are a few changes, this is still pretty much a direct quote, this is plagiarism. The reference (22, https://www.tandfonline.com/doi/full/10.1080/10550887.2012.694598) appears reliable, a good source.

Review of overall article:

Overall, this article is very fleshed-out and has many references, images, and great organization. Minor edits that I believe can be made include:

In the Dependence subheading: what is "upregulation"? The addition of an explanation for readers would be helpful.

In Other opioids subheading: "It is used in Switzerland and more recently in Canada.^96" could a year be added for Canada? "More recently" usually has a general connection to when this line was written, so a solid year would help for understanding the usage time-wise instead of having to find when the edit was made or search through the reference to totally understand how recently.

In Digital care programs subheading: Reference(s) would be preferable or a link/note directing towards more information on these programs.