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= Antibody based PET imaging =

Antibody PET imaging is a special field in Positron Emission Tomography (PET) which uses radio labelled Antibodies or their fragments as tracers. In contrast to commonly used small molecules as tracers, Antibodies profit from their specificity and high-affinity binding.

Antibody PET in Neurology
In the central nervous system, the uptake of antibodies is limited by the blood-brain barrier. Several preclinical attempts using active transporters for crossing the blood-brain barrier have demonstrated the potential of such tracers. Proteins binding to the transferrin receptor such as bi-specific fusion proteins have shown increased uptake compared non-modified proteins.

Amyloid specific fusion proteins are able to detect soluble species of Amyloid-beta in brain of transgenic mice. Disease progression and treatment effects after Bace-1 inhibition can be imaged in rodents.