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pH Low Insertion Peptide(pHLIP) A water-soluble membrane peptide that interacts weakly with a cell membrane at neutral pH, without insertion into the lipid bilayer, whereas at slightly acidic pH (<7.0) pHLIP inserts into the cell membrane and forms a stable transmembrane alpha-helix.

The combined effort of the three laboratories of Dr.Oleg Andreev (URI), Dr. Yana Reshetnyak (URI) and Dr. Donald Engelman (Yale University) directed toward the development of pHLIP nanotechnology platform for cancer imaging and treatment. pHLIP technology is based on the action of the pH (Low) Insertion Peptide.