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This is a list of actors and actresses playing major, recurring, or guesting characters on the US hit show Grey's Anatomy. The article includes list of major characters, list of reccuring characters and few lists of reccuring characters in every season.

Main cast
The following list shows the actors who at least appeared in one season like main character. The season(s) during which each actor has been included in the main cast are marked in light blue, while the season(s) during which a starring actor appeared as a guest star or was reccuring is marked in dark blue. The actors aren't listed by alphabetical order, instead they are listed by the way they are certified in the show.