User:Smbiophysics/Tunneling nanotube/Johnskad Peer Review

General info
Smbiophysics
 * Whose work are you reviewing?


 * Link to draft you're reviewing:User:Smbiophysics/Tunneling nanotube - Wikipedia
 * Link to the current version of the article (if it exists):Tunneling nanotube - Wikipedia

Evaluate the drafted changes
Your references in your bibliography look fantastic, all very up to date and relevant, along with being open access. Good work.

Nanotube membrane vs. Tunneling nanotube?? I think this is good to leave, its clarifying that they are not the same thing which they are not

Only animal cells? Or should this be made more broad to eukaryotic cells? '''You should examine this and likely change it. There is a section in the article about virus usage of TNTs, which are neither.'''

Specify the proteins involved in Tunneling Nanotube formation and inhibition '''Agreed, there should either be a reference here, or a short descriptor of the types of proteins involved. The majority of the detail should be saved for later though.'''

"Several mechanisms may be involved in nanotube formation. These include molecular controls as well as cell-to-cell interactions." This second sentence is vague and does not add valuable information. I will want to identify some of these specific molecular controls or cell-to-cell interactions in nanotube formation. This sentence does not stand on its own, but it does function as an introductory statement because specific cell-cell and melecular controls are discussed in the induction section.

Remove link from "BnL-FGF" gradient. Good

"Streamers" could use a description to describe what it is as a nanotube structure. '''I agree, this is a good spot to add clarification. Could also be a nice place to add a figure.'''

Myopodia in article has incorrect link to pseudopods. There is no link to Myopodia so I will need to remove it. Good idea, it might be worth adding something like "(similar to pseudopods)" if they are in fact similar, because more people will knwo what those are.

Add under main section:

Tunneling nanotubes are essential specifically for vertebrates in both embryonic development and tissue regulation.

-Difference between tunneling nanotubes and other cytoskeletal phenomenon like filopodia, is that tunneling nanotubes are the only ones that connect the cytoplasm of two cells.

Under Applications Section:

Tunneling nanotubes have the potential to be involved in the field of nanomedicine, as they have been shown the ability to inter-cellularly transfer such treatments.

Overall impressions
I like the ideas you have going. Your references are spot on, and they support the things you are looking to add. The first addition to the main section is a great idea, and helps introduce TNT importance. The second one is also good, but be careful because it may already be implied with the two types of TNT, one of which connects the cytoplasm one of which does not. The applications section addition looks good, flush out the idea and it will be a great addition. Overall you have a lot of good ideas to run with, and have done a great job identifying parts of the article to improve.