User:SmilauerovaKristyna/sandbox

= Ddi1-like protein family = Ddi1-like protein family is named after Ddi1 protein first found in yeast. Ddi1-like proteins share a common structure consisting of UBL (Ubiquitin-like) domain, a domain able to interact with ubiquitin (UBA, UIM, ...) and a RVP (retroviral protease-like) domain, which is specific for this family.

Homologs
Ddi1-like proteins are highly conserved among all eukaryotes, suggesting an important role within the organism.

Yeast
Ddi1 from Saccharomyces cerevisiae was the first described protein from this family. Its expression rate increased in cells with damaged DNA, suggesting it might take part in repair processes. Yeast Ddi1 functions as a shuttle protein for HO endonuclease and Ufo1 protein, influences cell cycle progression and vesicular transport.