User:Snow298/Thiamine monophosphate

Lead
Thiamine monophosphate, also known as ThMP and TMP, is a phosphate ester of thiamine. It is an intermediate from the hydrolysis of thiamine diphosphate to free thiamine by alkaline phosphatase. The conversion of ThMP to thiamine cannot be facilitated by acid hydrolysis. ThMP is also enzymatically synthesized by thiamine-phosphate pyrophosphorylase, which combines thiazole in its monophosphate form and pyrimidine as a pyrophosphate.

The physiological function of ThMP has not been identified.

Physiological presence
In whole human blood, both ThMP and free thiamine are present in lower concentrations as compared to TPP, but they are found in low amounts in plasma. ThMP and thiamine are the only phosphorylated thiamine derivatives found in human cerebral spinal fluid.

It is naturally occurring in bovine milk.

In rats, 64% of the total thiamine in plasma exists in its the monophosphate form. After injection of ThMP into the femoral vein of rats, it was quickly transported to the cerebral tissue without chemical modification, though the average transport rate was 5-10 times slower than that of thiamine. The average transport rate was 5-10 times slower than that of thiamine.