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The nineteenth series of the British medical drama television series Holby City commenced airing in the United Kingdom on 11 October 2016, and concluded on 19 December 2017. The series consists of 64 episodes. Oliver Kent continues his position as the show's executive producer and Simon Harper serves as the series producer until late 2016 when Kent was promoted, Harper became executive producer and Kate Hall was appointed the series producer. Fifteen regular cast members reprised their roles from the previous series, while several recurring characters, and numerous guest stars feature in the series. Following the departures of seven actors during the series, seven new characters were introduced, although new cast members David Ajao, Ayesha Dharker and Christian Vit depart before the series finale. Olga Fedori, Hermione Gulliford, Jaye Jacobs and Jemma Redgrave reprised their respective roles during the series, although Redgrave later departed the show.

Overview
The nineteenth series of Holby City began with 15 roles receiving star billing, a similar amount to the previous series. Guy Henry appears as chief executive officer and consultant general surgeon Henrik Hanssen. Hugh Quarshie stars as consultant general surgeon Ric Griffin, who is the clinical lead of general surgical ward, Keller ward, and later, the Acute Assessment Unit (AAU), as well as briefly the acting CEO. Catherine Russell portrays as Serena Campbell, the clinical lead of the AAU and a consultant general surgeon. Rosie Marcel acts as Jac Naylor, the clinical lead of the cardiothoracic surgery ward, Darwin, and a consultant cardiothoracic surgeon. John Michie plays consultant neurosurgeon Guy Self and Chizzy Akudolu appears as consultant cardiothoracic surgeon Mo Effanga. Bob Barrett stars as Sacha Levy, a consultant general surgeon and clinical skills teacher, who is later promoted to the clinical lead of Keller ward. James Anderson portrays Oliver Valentine, a cardiothoracic surgical registrar and later, a registrar general surgeon. Joe McFadden acts as registrar general surgeon Raf di Lucca. Camilla Arfwedson and David Ames play CT1 doctors and later, CT2 doctors, Zosia March and Dominic Copeland respectively. Eleanor Fanyinka appears as Morven Digby, a F2 doctor and the foundation doctor representative, who is later promoted to a CT1 doctor. Lucinda Dryzek stars as F1 doctor Jasmine Burrows. Alex Walkinshaw portrays Adrian "Fletch" Fletcher, the ward manager of the AAU and later, the directing of nursing services. Kaye Wragg acts as staff nurse and transplant co-ordinator Essie Harrison. Additionally, Ben Hull, Jules Robertson and Marc Elliott continue their semi-regular roles as consultant obstetrician-gynecologist Derwood "Mr T" Thompson, clinical audit assistant (and later, porter) Jason Haynes and registrar general surgeon Issac Mayfield respectively.

Hanssen departs in episode 3, although producers confirmed that the break is temporary and Henry would return. After appearing in episode 13, Hanssen returns in episode 18. In episode 6, Michie departs the series, although in June 2017, it was confirmed that he had reprised the role. Guy returns in episode 43, and departs again in episode 51. Russell decided to take a break from the drama in 2017 to travel and star in a production of What The Butler Saw. Serena departs in episode 26 after deciding to take a leave of absence to grieve for her daughter. At the conclusion of his domestic abuse storyline, Elliot left the show and Issac departs in episode 27. On 12 May 2017, it emerged that Akudolu was leaving the drama, and a month later, Akudolu revealed that Hull would also leave Holby City. Both characters depart the series together in episode 36 after moving to London. However, Akudolu suggested a possible return in the future, confirming that producers had left the door open. Dryzek opted to leave the series after a year and Jasmine is killed-off in episode 37 when she is stabbed by a scalpel. Dryzek told Victoria Wilson of What's on TV that she liked her exit, describing it as an "almighty way for Jasmine to bow out". On 10 September 2017, Arfwedson announced that she would be leaving the series. Zosia departs in episode 51 after deciding to move to America to further her career. In November 2017, McFadden hinted that he may leave the drama after appearing in Strictly Come Dancing had inspired him to try new roles. Raf departs in episode 62; his exit was kept out of spoilers for "maximum impact". Fanyinka also left the show during this series. Morven departs in episode 64 after deciding to volunteer in Jamaica.

On 13 September 2016, it was announced that Jemma Redgrave would return to her role as consultant general/trauma surgeon Bernie Wolfe. She returns in episode 7. On 25 July 2017, it was revealed that Redgrave would depart the series and Bernie would leave in episode 44. It was announced on 10 February 2017 that Jaye Jacobs would reprise her role as staff nurse Donna Jackson, having last appeared in the show's thirteenth series. Donna returns in episode 38. Former Casualty cast member Lee Mead was also confirmed to be joining Holby City as his character, staff nurse Ben "Lofty" Chiltern. Lofty arrives in episode 32. On 7 March 2017, it was revealed that Carli Norris had reprised her role as recurring character Fran Reynolds, an agency nurse who shares a backstory with Jac. She returns in episode 32. Having appeared in three episodes of series 15, Hermione Gulliford, who portrays consultant neurosurgeon Roxanna MacMillan, became a regular cast member in 2017. Roxanna returns in episode 55. On 4 October 2017, it was announced that Olga Fedori would reprise her role as cardiothoracic surgical registrar Frieda Petrenko. Harper warned viewers to "expect fireworks from these two huge personalities" when Frieda returns. Frieda returns in episode 63. Rob Ostlere reprised his role as Arthur Digby in episode 64, appearing as a hallucination during Morven's departure.

Christian Vit joined the cast as consultant cardiothoracic surgeon Matteo Rossini in 2016. Matteo arrives in episode 8. The castings of Ayesha Dharker and David Ajao as Nina Karnik and Damon Ford, respectively, were announced on 10 February 2017. Nina is a consultant general surgeon and the medical director, who is married to Matteo. Damon is a F1 doctor. Nina first appears in episode 31 and Damon joins in episode 36. Vit, Dharker and Ajao made unannounced departures from the drama in 2017: Damon departs in episode 59, and Matteo and Nina depart in episode 60. Billy Postlethwaite appears in episode 18 as Hanssen's son, Fredrik Johansson. Fredrik returns in episode 48 for 12 episodes, departing in episode 59. Fredrik also appears in episode 62, where he is killed-off after embarking on a mass shooting in the hospital. On 4 April 2017, it was announced that Paul McGann would join the cast as surgeon Professor John Gaskell in December. John is billed as a "surgical star with irrepressible charm". John debuts in episode 61. In August 2017, Hall told Daniel Kilkelly of entertainment website Digital Spy that the show was in the process of casting actresses in the roles of two F1 doctors. Belinda Owusu and Salma Hoque were cast as Nicky McKendrick and Meena Chowdhury respectively. Nicky and Meena are friends from school, although their friendship is tested by the hospital experience. Hall said that the doctors would "fight to survive" in the hospital as they come under scrutiny from Jac. Nicky and Meena first appear in episode 63.

Series 19 of Holby City features several former cast members reprising their roles for guest stints. Kaisa Hammarlund continues her role as bank nurse Inga Olsen, the fiancée of Mr T, until episode 13. Jonathan McGuiness, who portrays chairman of the board Tristan Wood, features in the series until episode 6, when he is killed-off. Recurring character Emma Naylor-Maconie, the daughter of Jac and Jonny Maconie (Michael Thomson), appears in three episodes across the series. Tessa Peake-Jones reprised her role as Imelda Cousins in episode 3, having last appeared in series 15. Peake-Jones compared returning to Holby City to "returning home". Caroline Lee-Johnson, who portrays Patsy Brassvine, appears in episode 4, having previously appeared in series 18. On 13 September 2016, it was revealed that Mark Healy had filmed another appearance as Robbie Medcalf, Serena's former partner. He appears in episode 5. Nic Jackman reprises his role as Bernie's son Cameron Dunn, who is an F1 doctor. He appears between episode 8 and 14, before returning in episodes 31 and 64. Jamie Nicholls appears in episode 11 as Lee Cannon, Dom's former boyfriend. Amy McCallum reprised her role as Elinor Campbell, Serena's daughter, in episode 12. Elinor is killed-off in episode 13. Dom's parents, Carole Copeland (Julia Deakin) and Barry Copeland (Nicholas Ball), were reintroduced in episode 14 for Dom's domestic abuse storyline. On 5 June 2017, it was revealed that Deakin would appear in the series again; Carole appears in episode 42. Fletch's eldest daughter, Evie Fletcher (Macey Chipping), reappears in episode 24. On 7 March 2017, it was revealed that Alan Morrissey would guest star in the series as Kyle Greenham, Dom's former boyfriend, having last appeared in the show's seventeenth series. Kyle appears in episode 27 for the conclusion of Dom's domestic abuse storyline. Following Jacobs' return to the drama, Donna's niece, Mia Barron, is reintroduced in episode 42, with Briana Shann recast in the role.

This series features multiple recurring characters and numerous guest stars. Louisa Clein joined the guest cast as Kim Whitfield, a love interest for Raf, in episode 1. Kim's son, Parker Whitfield (Louis Davison), was introduced in episode 2. They left in episode 10, although Clein reprised the role in episode 19 for three episodes. Davison returned in episode 22, joining the semi-regular cast. Parker continues appearing in the series until episode 53, which also features another appearance for Kim. Laura Rogers stars in episodes 4 to 6 as Tristan's partner, Jemima Chase. Susan Brown was cast as Birdie Thompson, the mother of Mr T, and she appears in episode 13. The character is reintroduced for one episode; Brown appears in episode 30. It was reported on 13 December 2016 that actress Gemma Oaten had joined the cast in a guest capacity. Oaten appears in episodes 27 and 28 as "bullish" agency nurse Sydney Summers, who clashes with Fletch. Fletch's youngest children, Ella Fletcher (Bo London) and Theo Fletcher (Stanley Rabbetts), appear in episode 47. Nick Rhys joins the cast in episode 56 as Jeremy Warren, the son of a patient who died under Ric's care. Jeremy arrives to find answers about his mother's death. Rhys filmed "seven or eight episodes" for the show. He departs in episode 64. Imogen Stubbs guest stars in episode 58 as Evelyn Chapman, the estranged mother of Morven.

Main characters

 * David Ajao as Damon Ford (episodes 35−59)
 * Chizzy Akudolu as Mo Effanga (until episode 36)
 * David Ames as Dominic Copeland
 * James Anderson as Oliver Valentine
 * Camilla Arfwedson as Zosia March (until episode 51)
 * Bob Barrett as Sacha Levy
 * Ayesha Dharker as Nina Karnik (episodes 31−60)
 * Lucinda Dryzek as Jasmine Burrows (until episode 37)
 * Eleanor Fanyinka as Morven Digby (until episode 64)
 * Olga Fedori as Frieda Petrenko (from episode 63)
 * Hermione Gulliford as Roxanna MacMillan (from episode 55)
 * Guy Henry as Henrik Hanssen (until episode 3, episode 13, from episode 18)
 * Salma Hoque as Meena Chowdhury (from episode 63)
 * Jaye Jacobs as Donna Jackson (from episode 38)
 * Rosie Marcel as Jac Naylor
 * Joe McFadden as Raf di Lucca (until episode 62)
 * Paul McGann as John Gaskell (from episode 61)
 * Lee Mead as Ben "Lofty" Chiltern (from episode 32)
 * John Michie as Guy Self (until episode 6, episodes 43−51)
 * Belinda Owusu as Nicky McKendrick (from episode 63)
 * Hugh Quarshie as Ric Griffin
 * Jemma Redgrave as Bernie Wolfe (episodes 7−44)
 * Catherine Russell as Serena Campbell (until episode 26)
 * Christian Vit as Matteo Rossini (episodes 8−60)
 * Alex Walkinshaw as Adrian Fletcher
 * Kaye Wragg as Essie Harrison

Recurring characters

 * Louis Davison as Parker Whitfield (episodes 2−10 and 22−53)
 * Marc Elliot as Issac Mayfield (until episode 27)
 * Kaisa Hammarlund as Inga Olsen (until episode 13)
 * Ben Hull as Derwood "Mr T" Thompson (until episode 36)
 * Nic Jackman as Cameron Dunn (episodes 8−14, 31 and 64)
 * Jonathan McGuiness as Tristan Wood (until episode 6)
 * Carli Norris as Fran Reynolds (episodes 32−40)
 * Billy Postlethwaite as Fredrik Johansson (episodes 18 and 48−62)
 * Nick Rhys as Jeremy Warren (episodes 56−64)
 * Jules Robertson as Jason Haynes

Guest characters

 * Nicholas Ball as Barry Copeland (episode 14)
 * Susan Brown as Birdie Thompson (episode 13 and 30)
 * Darcey Burke as Emma Naylor-Maconie (episodes 9, 47 and 60)
 * Macey Chipping as Evie Fletcher (episode 24)
 * Louisa Clein as Kim Whitfield (episodes 1−10, 19−21 and 53)
 * Julia Deakin as Carole Copeland (episodes 14 and 42)
 * Lloyd Everitt as Jez Andrews (episodes 16−17)
 * Mark Healy as Robbie Medcalf (episode 5)
 * Amanda Henderson as Robyn Miller (episode 32)
 * Poppy Jhakra as Amira Zafar (episodes 53 and 56)
 * Caroline Lee-Johnson as Patsy Brassvine (episode 4)
 * Bo London as Ella Fletcher (episode 47)
 * Tony Marshall as Noel Garcia (episode 23)
 * Amy McCallum as Elinor Campbell (episodes 12−13)
 * Alan Morrissey as Kyle Greenham (episode 27)
 * Jamie Nichols as Lee Cannon (episode 11)
 * Gemma Oaten as Sydney Somers (episodes 27−28)
 * Rob Ostlere as Arthur Digby (episode 64)
 * Tessa Peake-Jones as Imelda Cousins (episode 3)
 * Stanley Rabbetts as Theo Fletcher (episode 47)
 * Laura Rogers as Jemima Chase (episodes 4−6)
 * Briana Shann as Mia Barron (episode 42)
 * Michael Stevenson as Iain Dean (episode 62)
 * Imogen Stubbs as Evelyn Chapman (episode 58)