User:Soloxian

Cleanup INTERFEROME is an online bioinformatics database of interferon regulated genes (IRGs). It is used by the interferon (IFN) research community both as an analysis tool and an information resource. The database is regularly updated and new versions are released once a year. IFNs were identified as antiviral proteins more than 50 years ago. However, their involvement in immunomodulation, cell proliferation, inflammation and other homeostatic process has been since identified. These cytokines are used as therapeutics in many diseases such as chronic viral infections, cancer and multiple sclerosis. These IFNs regulate the transcription of approximately 2000 genes in a IFN subtype, dose, cell type and stimulus dependent manner. This database of IFN regulated genes is an attempt at integrating information from high-throughput experiments to gain a detailed understanding of IFN biology.

Contents
INTERFEROME comprises the following data sets:


 * Gene expresion data of IRGs from Homo sapiens, Mus musculus, and Pan troglodytes;
 * Manually curated from public and inhouse microarray and proteomic datasets;

Tools
INTERFEROME offers many ways of searching and retrieving data from the database:
 * Identify IRG signatures in microarray data;
 * Gene Ontology analysis;
 * Regulatory analysis of IRGs;
 * BLAST analysis and sequence download;

INTERFEROME Management
Interferome was develped at the Monash Institute of Medical Research