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Developmental and epileptic encephalopathies
Developmental and epileptic encephalopathies (DEE), also known as early infantile epileptic encephalopathies (EIEE), are a group of rare developmental disorders characterised by early onset epilepsy and severe developmental delay. The epilepsy typically starts under 2 years of age and can be difficult to treat (intractable). One of the most common is Dravet syndrome which is commonly caused by mutation to SCN1A. However, in approximately 2/3 of people with DEE a genetic cause cannot currently be found.