User:Ssbusse

10.1002/dvdy.24609

Plexin: There should be a lot more to add to this

Homework: 5 new sources for article and make a live edit on a real page

https://doi.org/10.1016/j.diff.2011.08.001

Purves

Structure article

Evolutionary separation between sema domain of plexin and sema domain of semaphorins, so original naming should be retained

Autoinhibitory and form dimers

neural network formation Peer Review

Hi! Thanks for updating this article! It clearly needed a lot of work and you have added a good amount of information to this page. Here I few things that came to my mind while reading this article:

Clarity, easy to understand

Since I didn't have any prior information about the topic it was a little difficult for me to understand some parts. In the intro section, if there was a sentence about where exactly plexin is found (what part of the neurons or nervous system) it would be helpful. You can start your sentence with something like this: Plexin is a membrane bound protein which was found in ....(sorry I don't exactly know where) part of the nervous system. This would give a better foundation to the reader to picture the plexin in their mind! Also, in the structure section " and glycine-proline-rich immunoglobulin domains shared by plexins and transcription factors (IPT). " I think mentioning the smilarity between IPT and plexins is not a good idea and kind of overwhelm the reader in one sentence. From my understanding of the plexins (I tried to read about it on Purves Neuroscience book) plexin is a member of the Ca2+-dependent cell adhesion molecules. I believe this is worth mentioning because it may connect the topic to some other concepts that the reader might already know of, such as other types of molecules in the Ca2+ dependent cell adhesion molecules and also because "cell adhesion molecules" is kind of self explanatory and helpful!

Recommendations for organization, new sections or subsections, order, or location of content

I believe in the structure section it would be helpful if you put the explanation for each structure right below each category name like this: The structure of the B class plexins has an additional extracellular site for cleavage by proprotein convertases, as well as a PDZ interaction motif on its C-terminus. C-class plexins have fewer MRS and IPT domains. D-class plexins have a modification in one of the MRS domains.
 * PLXNA1, PLXNA2, PLXNA3, PLXNA4A
 * PLXNB1, PLXNB2, PLXNB3
 * PLXNC1
 * PLXND1

And also give a one or two sentence about the A and D structure.

What other information would you like to know? What questions do you still have about the topic?

I mentioned some of my suggestions under the first question and I think the function section is very well-written and understandable but the structure section needs to have couple sentences more as I mentioned above. Also, I don't know if there are any publications regarding the diseases associated with plexin function but if there is any, I believe it would be worth mentioning since this information helps the reader to understand the importance of function of plexin.

Are there any terms that need definition, more information, or can be linked to other wiki pages.

I believe a lot of terms can be linked such as methionine-related sequences (MRS), angiogenesis, c-terminus, etc. basically all the new words that need prior knowledge to know the definition!

Is all the information relevant, not excessive, need to be on this page. Too much repeated from other pages?

Yes, I think all the information is needed.

Recommendations for speaking in a scientific tone; scientifically accurate, but not too technical.

I believe the function section is easier to understand than the structure section and it'd be better if rest of the sections be written with a less technical tone. But I'm not sure if that's doable considering the fact that the topic itself is very specific and technical. I think in the intro section the language is too technical and it would be more helpful if you could make it a little simpler (If possible).

How can images be improved, or what images would help clarify the page

An image of the plexin location in the membrane would be great.

Grammar

Grammar was fine :)