User:Step1 jan/sandbox

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Practice Editing Here (Nov 23rd in-class Wiki session work)

 * This is a place to practice clicking the "edit" button and practice adding references (via the citation button).
 * The name of my article is Chronic lymphocytic leukemia

Assignment # 3
Proposed Changes:

In the current version of the Wikipedia article on Chronic Lymphocytic Leukemia (CLL), under the “Causes” section, there is a single sentence about genetic causes:

"CLL is caused by multiple genetic mutations and epigenetic changes."

I proposed to add detail to this statement by elaborating and breaking it up into two sentences, one on genetic mutations and another on epigenetic changes:

"CLL can be caused by many different genetic mutations, the most common being deletions in the 13q14.3 region, (seen in 50% of CLL cases), as well as trisomy in chromosome 12 (seen in 20% of cases), other deletions (i.e., in 11q22-23, 17p13, or 16q21 regions), and less commonly, translocations (for example, involving the 13q14 region). CLL can also be caused by a number of epigenetic changes, which can be classified into 3 different methylation subgroups (naïve B-cell-like, memory B-cell-like, and intermediate)."

Rationale for proposed change:

The current information on the genetic causes of CLL is very sparse and vague. It mentions there being genetic causes, but does not specify which mutations may cause CLL, what kind of mutations they are, or which epigenetic changes can cause it. Furthermore, this statement is not accompanied by a source. For this reason, my change elaborates on the genetic and epigenetic causes of CLL, and provides several examples, taken from a credible source.

There is some disagreement in this article’s Talk page surrounding the genetic changes in CLL, where some argue that most CLL mutations are translocations, while others argue that there are no translocations in the disease. The reality, according to my source, is that there are some translocations, but they are uncommon and may be secondary to other mutations. This is what I have chosen to include in my changes, as well as a mention of more common mutations.

Critique of Source:

This source was chosen because, as an academic book, it is a credible source based on a large amount of sources accumulated by experts in the field, thus minimizing bias. Furthermore, since it is published by a credible international organization (WHO), it is reliable and has undergone strict review. However, a downside of this source is that it was published in 2017, and therefore may be outdated compared to more recent research papers. As such, there may have been new advancements in CLL research since the book was written that it does not account for. Additionally, if the primary sources used in the book only contain published research, publication bias may exist within the resource.

What to post on the Wikipedia article talk page?

 * This will also be covered on Nov 23rd in class. Your group should use the below template to share an outline of your proposed improvements (including your new wording and citations). Article talk pages are not places to share your assignment answers. The Wikipedia community will be more interested in viewing your exact article improvement suggestions including where you plan to improve the article (which section), what wording you suggest, and the exact citation (Note: all citations must meet WP:MEDRS)
 * You will not be able to paste citations directly from your sandbox to talk pages (unless you are interested in editing/learning Wiki-code in the "source editing" mode). We suggest re-adding your citations on the talk page manually (using the cite button and populating the citation by pasting in the DOI, website, or PMID). You will have to repeat this process yet again when you edit the actual article live.
 * Talk Page Template: CARL Medical Editing Initiative/Fall 2020/Talk Page Template