User:StephenBorders2199/sandbox

As explained, ALX3 codes for making a protein that is a member of the homeobox family that helps with development but with mutations of the gene it can cause frontonasal dysplasia. This effect the development of the facial structure causing deformities mostly in the nose and mouth area. On a genetic level, this is caused by the ALX3 protein not functioning properly or to not do so in entirety. Since the ALX3 protein is a transcription factor which implies that it binds to the DNA in order to control genes that preform cellular division and growth without this regulator it is bound to have negative effects in the development stages with serious consequences. This causes “clefts” which is openings in the nose and can also cause improper formation of the skull going as far as malformations of the tissue that joins the halves of the brain which can cause mental disabilities instead of just physical. Another serious possibility is the possibility of incomplete formation of the skull to a degree where there is only skin covering the head where bone should be. Whereas many of these may seems to more of a cosmetic issue along with intellectual disabilities the misfunction of the ALX3 gene can cause death. Depending on the issue, this autosomal recessive inheritance condition can be fatal especially without immediate medical attention for serious cases. This abnormality has three different types which all carry their own consequences but most commonly is type one which is the condition described above but the other two could include hair loss, genital abnormalities in males, eyes that are missing, and wide-set ears. Frontonasal dysplasia is a very rare autosomal condition, but this is the serious result of misfunction of the ALX3 gene and protein.