User:Subclavian

Utriv 09:41, 15 May 2007 (UTC)Utriv

Hello Subclavian:

The signaling illustration that you have for the TLRs is very nice, but omits Mal (Tirap). Can you add that adapter protein? It contributes to MyD88-dependent signaling.

Utriv

--Subclavian 05:39, 3 June 2007 (UTC)

Hi Utriv: Thanks for pointing that out. I've added TIRAP into the diagram.

subclavian

Hello Subclavian:

several sources explain, that TRIF activates RIP1, which then activates the IKKs. This is said to be part of the MyD88-independent signaling, together with the TBK1-signaling.