User:Sven625

https://en.wikipedia.org/wiki/Eomesodermin https://en.wikipedia.org/wiki/Chromosome_conformation_capture#Carbon-Copy_Chromosome_Conformation_Capture_.285C.29 (doesn't have any info on new techniques) https://en.wikipedia.org/wiki/AKAP5 https://en.wikipedia.org/wiki/N-Methyl-D-aspartic_acid https://en.wikipedia.org/wiki/AMPA

Final Pick: https://en.wikipedia.org/wiki/Eomesodermin

sources: http://www.nature.com/ncb/journal/v13/n9/full/ncb2304.html http://www.jneurosci.org/content/25/1/247.full http://genesdev.cshlp.org/content/22/18/2479.full http://www.cell.com/neuron/abstract/S0896-6273(08)00807-6 http://cercor.oxfordjournals.org/content/early/2014/06/13/cercor.bhu125.full

notes: 1) "Eomes acts cooperatively with the Nodal/Smad2/3 pathway to promote delamination of nascent mesoderm and specification of APS fates"    -APS: anterior primitive streak

2) "Eomes expression is initiated in the prospective posterior aspect of the epiblast at embryonic day 5.75", "Inactivation of Eomes in the epiblast results in a severe block in EMT and arrests development at gastrulation" "Eomes-expressing cells thus give rise to two discrete progenitor cell populations during gastrulation, namely the prospective cranial and cardiac mesoderm that emerge from the primitive streak at early stages, and APS derivatives giving rise to the definitive endoderm, node and notochord."

Plan:

My plan of action to revise the Eomesodermin page is to talk more heavily about the protein's specific roles in development. Currently, the page simply states that T box genes are involved in developmental processes. Most other development information is my own. In order to obtain this information, I plan to thoroughly read the above cited sources from various papers, and translate the information into a more user friendly language. I will parse through the scientific jargon, and attempt to relate the concepts to various other pages as well. In this way, I hope to create a network of references and links for those eager to find more information about Eomesodermin. As for information already gathered, my reading of the above papers has taught me that Eomesodermin contributes to the formation of the primitive streak which forms the mesoderm in the blastula during development and contributes to formation the notochord, which controls the beginning of neural development. In describing Eomesodermin, I will briefly talk about embryonic development, its roles in development, and its long lasting effects on development. I will expand the page's links so that readers can learn more about the primitive streak, notochord, etc. on their own pages as well. Additionally, I will recommend useful papers in development. Moreover, I plan to talk about current areas of research, and confusing information involving Eomesodermin. For example, a recent paper (2015) connected Eomesodermin mutations with Alzheimer's Disease. As this is one paper, I will not conclusively state the relation, but I will give it some credit. Additionally, I will talk about how Eomesodermin specifically related to the Tbr1 subfamily, as this seems like a confusing point on the page itself. In this way, I hope to clear misconceptions about Eomesodermin and excite readers to new areas of research.