User:Swathichowdary123/Evaluate an Article

Which article are you evaluating?
Anticancer gene

Why have you chosen this article to evaluate?
I chose this topic because i was very much interested in this since my under graduation. I always wanted to do research on this but never really got a chance to work on anticancer genes, I wonder how these cells kill only cancer-causing cells without destroying normal cells, the curiosity to learn more about cancer gene therapy, I decided to analyze this article so that i can learn more about gene transfer, immunotherapy, and oncolytic virotherapy.

Evaluate the article
The genes that destroy tumor causing cells without destroying normal cells are called Anticancer cells. This destruction involves many mechanisms, including mitotic catastrophe and apoptosis.

Anticancer genes were discovered in 1990s.

As of now we have 291 anticancer gens in human genome, arranged to be identified as a cancer-fighting gene it should have base replacements relating to protein codes are further altered by deletions and amino acid alterations that result in frameshifts. These anticancer genes can be used as therapeutics. The advancement in therapeutics increases the patient survival rates.

Some of the examples of such therapeutics:

Apoptin, TRAIL, PAR-4, HAMLET, MDA-7, NOXA.

APOPTIN- is the first anticancer gene which derives from the chicken anemia virus's genome's solitary circular DNA strand. This protein is also called as viral protein.

There are some common misunderstandings that a gene is always when compared to the proteins they encode for (figure 7) explains it clearly.

NOXA- NOXA is isolated from mice, it controls cell death through intracellular stress signals.

MDA-7: It is also called as IL-24, it is discovered using subtraction hybridization.

HAMLET: It isa cancer-fighting protein that is present in breast milk. It was first discovered in 1995 during the study of how breast milk influences lung cancer-causing bacteria.

ORCTL3: organic cation delivered as like-3; initially identified during large scale DNA sequencing with the tumor specific apoptosis activity.

These genes act as a code that creates noncoding ribonucleic acids which consists of several effects like to prevent cancer within cells.

This article explained clearly about history and action of therapeutics, but i feel they could have made it even more clear by inserting images of action for E4oef4, HAMLET, MDA-7