User:Syedajannath1/Reductive stress

Although different organelles may each have a different redox status, through probing for factors such as glutathione and H202, it was determined that reductive stress is present in the Endoplasmic Reticulum of senescent cells. Reductive stress is significant in the aging process of a cell and when ER oxidation status is elevated, cellular aging slowed. In particular, when reductive stress is increased, it results may result in many downstream effects such as increased apoptosis, decreased cell survival, and mitochondrial dysfunction, all of which need to be properly regulated to ensure that the needs of the cell are met. Reductive stress is present in many diseases with abnormalities such as the increase of reducing equivalents, resulting in issues such as hypoxia-induced oxidative stress.