User:T.leepharmacy/sandbox

estrone- side effects, adverse effects, contraindications (find sources from systematic reviews and meta analyses)

Estrone

Contraindications
The use of estrone has several contraindications, some examples including: hypersensitivity, history of some cancers, stroke, venous thromboembolism (VTE), and those currently pregnant or breastfeeding. Estrogens hold a boxed warning to be used at the lowest effective dose and for the shortest possible treatment period if used alone or with another hormone in the progestogen class

Breast Cancer
Estrone is contraindicated for those that have or are suspected of having breast cancer. The use of estrogens hold a boxed warning with breast cancer for post-menopausal individuals as this can increase the risk of developing invasive breast cancer. Those with breast cancer become at a greater risk of hypercalcemia and bone metastases when taking estrogens. Post-menopausal individuals with breast cancer can be seen to develop frailty syndrome when there are changes in blood hormonal levels, including an increased level of estrone. Estrone, the major type of estrogen produced in post-menopausal individuals, was seen in greater concentrations from standard levels in those that were categorized as prefrail and in those that classified as frail.

Venous Thromboembolism
The risk of VTE is increased in those that use estrogens, those that currently have or have a history with VTE are at a greater risk of reoccurring VTE with the usage of estrogens. The use of estrogens within three weeks postpartum may increase the risk of developing a VTE. Risk of developing initial VTE is also increased with familial history, genetic mutations: factor V Leiden and prothrombin-G20210A, and pregnancy-postpartum with the use of estrogens.

Breastfeeding
The use of estrogens may affect the ability to breastfeed and can change the composition of breastmilk. Estrogens have been used to suppress lactation which can result in a reduced total duration of lactation and reduced volume or inability to produce breastmilk. Composition of breastmilk produced was also seen to be different resulting in a reduced concentration of proteins in the milk. Babies of mothers that were taking estrogens while breastfeeding were seen to experience slower weight gain.

Common
Some common side effects seen with the usage of estrogens include: breast swelling, breast tenderness, vaginal itching, abnormal uterine bleeding, weight gain, hair loss, jaundice, and anaphylaxis.

Adverse effect
Some adverse effects seen with the usage of estrogens include: increased risk of venous thromboembolism (VTE), stroke, breast cancer, hypertension, and vaginitis.

Do the group’s edits substantially improve the article as described in the Wikipedia peer review “Guiding framework”? The group's edits so far have improved the article from their starting point. Lots of good information added and filling in some of the gaps of the information that was not included from the original state. The added information was non-biased and not giving a diagnosis, but providing information. Language used was easy to understand and when using more scientific/difficult terms hyperlinks were provided to their respective pages.

Has the group achieved its overall goals for improvement? The intended goals to improve the article were met, great job!

'''Do the edits reflect language that supports diversity, equity, and inclusion? (explain)''' I think the addition of the "ambiguous genitalia" portion was great in addressing this that could even be later linked to inclusion of information for those that are transgender, nonbinary, etc. if there are studies on this. The topic may be specific to the male genitalia, but you may consider want to consider using inclusive language for those that are transgender, nonbinary, etc. that have male genitalia by using something like "individuals" at times.

Providing tobacco cessation treatment etc.