User:T NVLSL Navya sri/Bivalent Genome

== Article Draft ==

=== Altogether, these data suggest that bivalent chromatin protects promoters from de novo DNA methylation and irreversible silencing while maintaining a reversibly repressed state, and that loss of H3K4me3 may make these genes more susceptible to aberrant DNA methylation in cancer. The core histones H2A H2B H3 AND H4 Methylation of interest of modifications are catalysed and also H3k27me3 and H3K4me3 prove distinct cell cycle patterning: H3K4me3 is restored and mitosis and displays cell cycle, whereas H3K27me3 is restore after mitosis and constant. Bivalent domains, shows 3D confirmation in stem cells that will be distributed in differentiation. Bivalency is a chromatin property that is tightly linked to stem cells and also domains in pluripotent stem cells methylation same regions as markers ===

=== Article body histone H3 lys27 methylation have ES cells were examined across of HCNE regions in ES and differentiation cells and also found 192 Lys27-methylated sites across these regions these affects larger genomic regions than the lys4 sities  ===