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B12 and Dorothy Hodgkin
In 1948, at a biochemical meeting in Oxford, Lester Smith, a researcher from Glaxo, brought his first crystals of vitamin B12. Hodgkin created new crystals from some of his less useful crystals, and deduced the presence of a ring structure because the crystals were pleochroic, a finding which she later confirmed using X-ray crystallography. Scientists from Merck had previously crystallised B12, but had published only refractive indices of the substance.

The final structure of Vitamin B12 was published in 1955.